About
PERSONAL
INFORMATION
Full Name
Birthday:
Place of birth:
Addresses:
Telephone:
E-mail:
Marital status:
Astghik Hakobyan
19.02.1989
Yerevan, Armenia
1) str Isahakyan 38, apt 55; Yerevan, Armenia
2) K.Ulnetsi 1 st deadlock, building 4, apt 36; Yerevan, Armenia
(+374 41) 446608, /Viber, Whatsup Telegram/
[email protected];
[email protected];
Married, one child.
WORK EXPERIENCE
2022-present
2019 February-
present
Lecturer at NAS RA. Department of Molecular and Cellular Biology. Course of
General Virology
Lecturer at Russian-Armenian university. Course of General Virology.
2012-present Researcher, Young scientist
Institute of Molecular Biology of NAS (Yerevan, Armenia)
(http://molbiol.sci.am/resun_antdefmech)
EDUCATION
2013-2017 PhD in Biology,
Title of thesis: “Swine blood coagulation system pathology during the infection of
African swine fever virus”
2005-2011 Master degree.
Russian – Armenian (Slavonic) State University, Faculty of Medical Biology, Class-
Medical Biochemistry, Qualification – Doctor-Biochemist, degree with honors.
Diploma project, Master’s thesis title: “The possible influence of Transcription
Factors on Development of Diabetic Neuropathy”
2003 – 2005 School № 55 after A.P.Chekhov,
Advanced Highers: Chemistry - 20(excellent); Biology - 5 (excellent), Physics - 5
(excellent)
Highers: Algebra and Elements of Analysis 5 (excellent), English – 5(excellent)
1995-2003 School № 67 after E. Charents
SKILLS AND EXPERIENCE
Grow and maintenance of cell cultures; DNA extraction, PCR, ELISA, Image
scanning cytometry, DNA measurement, western blotting, work with viruses (virus
titration, antiviral compounds screening, Time of addition assays design), statistical
analysis.
Fast learning, easy explaining.
GRANTS
2024 Ministry of Education and Science of Armenia, State committee of science
24WS-1F045 PI․ MAPK/ERK Pathway inhibitors as novel antiviral compounds
2021 Ministry of Education and Science of Armenia, State committee of science
21T-1F158 Team member. Descovery of new antiviral compounds that target
nucleotide biosynthesis enzymes.
2020 Ministry of Education and Science of Armenia, State committee of science
20TTSG-1F007Team member . Discovery of new broad-spectrum antiviral agents
2019 Ministry of Education and Science of Armenia, State committee of science
19YR-1F039 Team member. Creation of a high-throughput screening system for the
detection of antiviral agents. Group member
2019 Armenian National Science and Education Fund
“In silico and in vitro screening and testing of antiviral compounds aginst FMDV”, PI
2019 Armenian National Science and Education Fund
“Role of polyamines in african swine fever virus infection” group member
2018-2020 Ministry of Education and Science of Armenia, State committee of science
18RF-034 “Nanocomplexes of nucleotide and oligonucleotide analogues as antiviral
agents against african swine fever virus” group member
2017 Armenian National Science and Education Fund NS Microbio-4469
Project title: “Antiviral activity of apigenin against african swine fever virus arm07
strain”, PI
2016-2018 Ministry of Education and Science of Armenia, State committee of science
16YR-1F064, Project title: “Evaluation of antiviral activity of apigenin chemical
derivatives against African swine fever virus”, group member
2015 Armenian National Science and Education Fund , NS biotech-3751
Project title: “A study of flavonoids as antiviral agents”, group member
2015-2017 Ministry of Education and Science of Armenia, State committee of science
15RF-081; “Inhibition of african swine fever virus by antiviral water-soluble perylene
nucleoside analogues”, group member
ADDITIONAL INFORMATION
IT skills Excellent knowledge of MS Windows, MS Word, MS Excel, MS Access, MS
PowerPoint, MS Project, Corel Draw, Adobe Photoshop, Internet User
Personal membership Member of young scientist’s union, Institute of molecular biology, NASRA
Languages English- good
Russian-fluent
Armenian –native
German- basic with dictionary
ACTIVITIES
Volunteering for Foundation for Armenian Science and Technology (FAST)
https://fast.foundation/#/community
Member of organizing committee “Pan-Armenian Scientific Forum”
http://psc.egac.am/
Member of “Events and conferences” organizing committee of Institute of
Molecular Biology, NAS RA
Member of organizing committee “FEBS advance lecture course” 2016, 2019
INTERESTS Choreograpy, Innovations, History, Networking.
LIST OF PUBLICATIONS
1. Levon Kharatyan, Smbat Gevorgyan, Hamlet Khachatryan, Anastasiya Shavina, Astghik
Hakobyan, Mher Matevosyan & Hovakim Zakaryan. Data-driven discovery of chemical signatures
for developing new inhibitors against human influenza viruses. BMC Chemistry 19, 159 (2025).
https://doi.org/10.1186/s13065-025-01540-z
2. Jackman JA, Hakobyan A, Grigoryan R, Izmailyan R, Elrod CC, Zakaryan H. Antiviral screening
of natural, anti-inflammatory compound library against African swine fever virus. Virol J. 2024 Apr
25;21(1):95. doi: 10.1186/s12985-024-02374-2. PMID: 38664855; PMCID: PMC11046949.
3. Samvel Sirakanyan, Erik Arabyan, Astghik Hakobyan, Tamara Hakobyan, Garri Chilingaryan,
Harutyun Sahakyan, Arsen Sargsyan, Grigor Arakelov, Karen Nazaryan, Roza Izmailyan, Liana
Abroyan, Zaven Karalyan, Elina Arakelova, Elmira Hakobyan, Anush Hovakimyan, Andre
Serobian, Marco Neves, João Ferreira, Fernando Ferreira, Hovakim Zakaryan. A new microtubule-
stabilizing agent shows potent antiviral effects against African swine fever virus with no
cytotoxicity. https://doi.org/10.1080/22221751.2021.1902751
4. Erik Arabyan, Astghik Hakobyan, Tamara Hakobyan, Rafaella Grigoryan, Roza Izmailyan, Aida
Avetisyan, Zaven Karalyan, Joshua A Jackman, Fernando Ferreira, Charles C Elrod, Hovakim
Zakaryan.Flavonoid library screening reveals kaempferol as a potential antiviral agent against
african swine fever virus. Front. Microbiol., 21 October 2021. Sec. Virology. Volume 12 - 2021 |
https://doi.org/10.3389/fmicb.2021.736780.
5. Astghik Hakobyan, Karalyan Zaven, Armen Kotsinyan, Fernando Ferreira, Karen Nazaryan, Erik
Arabyan, Vahram Arakelov, Harut Sahakyan, Hovakim Zakaryan. Inhibition of African swine fever
virus infection by genkwanin. Antiviral Res. https://doi.org/10.1016/j.antiviral.2019.04.008
6. Erik Arabyan, Astghik Hakobyan, Armen Kotsinyan, Zaven Karalyan, Vahram Arakelov, Grigor
Arakelov, Karen Nazaryan, Anna Simonyan, Rouben Aroutiounian, Fernando Ferreira, Hovakim
Zakaryan. Genistein inhibits African swine fever virus replication in vitro by disrupting viral DNA
synthesis. Antiviral Res. 2018 Aug;156:128-137. doi: 10.1016/j.antiviral.2018.06.014
7. Weber S, Hakobyan A, Zakaryan H, Doerfler W. Intracellular African swine fever virus DNA
remains unmethylated in infected Vero cells. Epigenomics. 2018 Jan 12. doi: 10.2217/epi-2017-
0131. [Epub ahead of print] PMID: 29327614
8. Hakobyan A, Galindo I, Nañez A, Arabyan E, Karalyan Z, Chistov AA, Streshnev PP, Korshun
VA, Alonso C, Zakaryan H. Rigid amphipathic fusion inhibitors demonstrate antiviral activity
against African swine fever virus. J Gen Virol. 2018 Jan;99(1):148-156. doi: 10.1099/jgv.0.000991.
Epub 2017 Dec 13. PMID: 29235978
9. Hakobyan A, Arabyan E, Avetisyan A, Abroyan L, Hakobyan L, Zakaryan H. Apigenin inhibits
African swine fever virus infection in vitro. Arch Virol. 2016 Dec;161(12):3445-3453.
10. Karalova E., Zakaryan H., Voskanyan H., Arzumanyan H., Hakobyan A., Nersisyan N., Saroyan
D., Karalyan N., Tatoyan M., Akopian J., Gazaryantz M., Mkrtchyan Z., Pogosyan L., Nersesova L.,
Karalyan Z., 2015 Clinical and post-mortem investigations of genotype II induced African swine
fever. Porc Res 5(1):1-11.
11. Hakobyan A. V., Bayramyan N. V., Tusuzyan A. T., Semrjyan Z. B. Morphology and
cytophotometry of thrombocytopoetic cells in pigs. 2015, 1(19), 54-59.
12. Zakaryan H, Karalova E, Voskanyan H, Ter-Pogossyan Z, Nersisyan N,
Hakobyan A, Saroyan D, Karalyan Z. Evaluation of hemostaseological status ofpigs experimentally
infected with African swine fever virus. Vet Microbiol. 2014 Sep 6. pii: S0378-1135(14)00405-2.
doi: 10.1016/j.vetmic.2014.08.029.
13. Hakobyan A.V Coagulopathy during acute African Swine Fever Virus А. Pharma, 2014, №9 p. 60-
63
14. Karalova E.M., Arzumanyan H.A., Mirzoyan A.F., Hakobyan A.V., Karalyan Z.A. Patanatomical
description of the acute African swine fever in experiment. Veterinary medicine 97, Feodosya,
Ukrain, 2013, 97, 98-100.
Chapter in a book:
E. Arabyan, A. Kotsinyan, A. Hakobyan and Hovakim Zakaryan . African Swine Fever Virus.
Pages: 1-20.DOI: https://doi.org/10.21775/9781910190913.01 Porcine Viruses: From Pathogenesis to
Strategies for Control. Publisher: Caister Academic Press Edited by: Hovakim Zakaryan
INFORMATION
Full Name
Birthday:
Place of birth:
Addresses:
Telephone:
E-mail:
Marital status:
Astghik Hakobyan
19.02.1989
Yerevan, Armenia
1) str Isahakyan 38, apt 55; Yerevan, Armenia
2) K.Ulnetsi 1 st deadlock, building 4, apt 36; Yerevan, Armenia
(+374 41) 446608, /Viber, Whatsup Telegram/
[email protected];
[email protected];
Married, one child.
WORK EXPERIENCE
2022-present
2019 February-
present
Lecturer at NAS RA. Department of Molecular and Cellular Biology. Course of
General Virology
Lecturer at Russian-Armenian university. Course of General Virology.
2012-present Researcher, Young scientist
Institute of Molecular Biology of NAS (Yerevan, Armenia)
(http://molbiol.sci.am/resun_antdefmech)
EDUCATION
2013-2017 PhD in Biology,
Title of thesis: “Swine blood coagulation system pathology during the infection of
African swine fever virus”
2005-2011 Master degree.
Russian – Armenian (Slavonic) State University, Faculty of Medical Biology, Class-
Medical Biochemistry, Qualification – Doctor-Biochemist, degree with honors.
Diploma project, Master’s thesis title: “The possible influence of Transcription
Factors on Development of Diabetic Neuropathy”
2003 – 2005 School № 55 after A.P.Chekhov,
Advanced Highers: Chemistry - 20(excellent); Biology - 5 (excellent), Physics - 5
(excellent)
Highers: Algebra and Elements of Analysis 5 (excellent), English – 5(excellent)
1995-2003 School № 67 after E. Charents
SKILLS AND EXPERIENCE
Grow and maintenance of cell cultures; DNA extraction, PCR, ELISA, Image
scanning cytometry, DNA measurement, western blotting, work with viruses (virus
titration, antiviral compounds screening, Time of addition assays design), statistical
analysis.
Fast learning, easy explaining.
GRANTS
2024 Ministry of Education and Science of Armenia, State committee of science
24WS-1F045 PI․ MAPK/ERK Pathway inhibitors as novel antiviral compounds
2021 Ministry of Education and Science of Armenia, State committee of science
21T-1F158 Team member. Descovery of new antiviral compounds that target
nucleotide biosynthesis enzymes.
2020 Ministry of Education and Science of Armenia, State committee of science
20TTSG-1F007Team member . Discovery of new broad-spectrum antiviral agents
2019 Ministry of Education and Science of Armenia, State committee of science
19YR-1F039 Team member. Creation of a high-throughput screening system for the
detection of antiviral agents. Group member
2019 Armenian National Science and Education Fund
“In silico and in vitro screening and testing of antiviral compounds aginst FMDV”, PI
2019 Armenian National Science and Education Fund
“Role of polyamines in african swine fever virus infection” group member
2018-2020 Ministry of Education and Science of Armenia, State committee of science
18RF-034 “Nanocomplexes of nucleotide and oligonucleotide analogues as antiviral
agents against african swine fever virus” group member
2017 Armenian National Science and Education Fund NS Microbio-4469
Project title: “Antiviral activity of apigenin against african swine fever virus arm07
strain”, PI
2016-2018 Ministry of Education and Science of Armenia, State committee of science
16YR-1F064, Project title: “Evaluation of antiviral activity of apigenin chemical
derivatives against African swine fever virus”, group member
2015 Armenian National Science and Education Fund , NS biotech-3751
Project title: “A study of flavonoids as antiviral agents”, group member
2015-2017 Ministry of Education and Science of Armenia, State committee of science
15RF-081; “Inhibition of african swine fever virus by antiviral water-soluble perylene
nucleoside analogues”, group member
ADDITIONAL INFORMATION
IT skills Excellent knowledge of MS Windows, MS Word, MS Excel, MS Access, MS
PowerPoint, MS Project, Corel Draw, Adobe Photoshop, Internet User
Personal membership Member of young scientist’s union, Institute of molecular biology, NASRA
Languages English- good
Russian-fluent
Armenian –native
German- basic with dictionary
ACTIVITIES
Volunteering for Foundation for Armenian Science and Technology (FAST)
https://fast.foundation/#/community
Member of organizing committee “Pan-Armenian Scientific Forum”
http://psc.egac.am/
Member of “Events and conferences” organizing committee of Institute of
Molecular Biology, NAS RA
Member of organizing committee “FEBS advance lecture course” 2016, 2019
INTERESTS Choreograpy, Innovations, History, Networking.
LIST OF PUBLICATIONS
1. Levon Kharatyan, Smbat Gevorgyan, Hamlet Khachatryan, Anastasiya Shavina, Astghik
Hakobyan, Mher Matevosyan & Hovakim Zakaryan. Data-driven discovery of chemical signatures
for developing new inhibitors against human influenza viruses. BMC Chemistry 19, 159 (2025).
https://doi.org/10.1186/s13065-025-01540-z
2. Jackman JA, Hakobyan A, Grigoryan R, Izmailyan R, Elrod CC, Zakaryan H. Antiviral screening
of natural, anti-inflammatory compound library against African swine fever virus. Virol J. 2024 Apr
25;21(1):95. doi: 10.1186/s12985-024-02374-2. PMID: 38664855; PMCID: PMC11046949.
3. Samvel Sirakanyan, Erik Arabyan, Astghik Hakobyan, Tamara Hakobyan, Garri Chilingaryan,
Harutyun Sahakyan, Arsen Sargsyan, Grigor Arakelov, Karen Nazaryan, Roza Izmailyan, Liana
Abroyan, Zaven Karalyan, Elina Arakelova, Elmira Hakobyan, Anush Hovakimyan, Andre
Serobian, Marco Neves, João Ferreira, Fernando Ferreira, Hovakim Zakaryan. A new microtubule-
stabilizing agent shows potent antiviral effects against African swine fever virus with no
cytotoxicity. https://doi.org/10.1080/22221751.2021.1902751
4. Erik Arabyan, Astghik Hakobyan, Tamara Hakobyan, Rafaella Grigoryan, Roza Izmailyan, Aida
Avetisyan, Zaven Karalyan, Joshua A Jackman, Fernando Ferreira, Charles C Elrod, Hovakim
Zakaryan.Flavonoid library screening reveals kaempferol as a potential antiviral agent against
african swine fever virus. Front. Microbiol., 21 October 2021. Sec. Virology. Volume 12 - 2021 |
https://doi.org/10.3389/fmicb.2021.736780.
5. Astghik Hakobyan, Karalyan Zaven, Armen Kotsinyan, Fernando Ferreira, Karen Nazaryan, Erik
Arabyan, Vahram Arakelov, Harut Sahakyan, Hovakim Zakaryan. Inhibition of African swine fever
virus infection by genkwanin. Antiviral Res. https://doi.org/10.1016/j.antiviral.2019.04.008
6. Erik Arabyan, Astghik Hakobyan, Armen Kotsinyan, Zaven Karalyan, Vahram Arakelov, Grigor
Arakelov, Karen Nazaryan, Anna Simonyan, Rouben Aroutiounian, Fernando Ferreira, Hovakim
Zakaryan. Genistein inhibits African swine fever virus replication in vitro by disrupting viral DNA
synthesis. Antiviral Res. 2018 Aug;156:128-137. doi: 10.1016/j.antiviral.2018.06.014
7. Weber S, Hakobyan A, Zakaryan H, Doerfler W. Intracellular African swine fever virus DNA
remains unmethylated in infected Vero cells. Epigenomics. 2018 Jan 12. doi: 10.2217/epi-2017-
0131. [Epub ahead of print] PMID: 29327614
8. Hakobyan A, Galindo I, Nañez A, Arabyan E, Karalyan Z, Chistov AA, Streshnev PP, Korshun
VA, Alonso C, Zakaryan H. Rigid amphipathic fusion inhibitors demonstrate antiviral activity
against African swine fever virus. J Gen Virol. 2018 Jan;99(1):148-156. doi: 10.1099/jgv.0.000991.
Epub 2017 Dec 13. PMID: 29235978
9. Hakobyan A, Arabyan E, Avetisyan A, Abroyan L, Hakobyan L, Zakaryan H. Apigenin inhibits
African swine fever virus infection in vitro. Arch Virol. 2016 Dec;161(12):3445-3453.
10. Karalova E., Zakaryan H., Voskanyan H., Arzumanyan H., Hakobyan A., Nersisyan N., Saroyan
D., Karalyan N., Tatoyan M., Akopian J., Gazaryantz M., Mkrtchyan Z., Pogosyan L., Nersesova L.,
Karalyan Z., 2015 Clinical and post-mortem investigations of genotype II induced African swine
fever. Porc Res 5(1):1-11.
11. Hakobyan A. V., Bayramyan N. V., Tusuzyan A. T., Semrjyan Z. B. Morphology and
cytophotometry of thrombocytopoetic cells in pigs. 2015, 1(19), 54-59.
12. Zakaryan H, Karalova E, Voskanyan H, Ter-Pogossyan Z, Nersisyan N,
Hakobyan A, Saroyan D, Karalyan Z. Evaluation of hemostaseological status ofpigs experimentally
infected with African swine fever virus. Vet Microbiol. 2014 Sep 6. pii: S0378-1135(14)00405-2.
doi: 10.1016/j.vetmic.2014.08.029.
13. Hakobyan A.V Coagulopathy during acute African Swine Fever Virus А. Pharma, 2014, №9 p. 60-
63
14. Karalova E.M., Arzumanyan H.A., Mirzoyan A.F., Hakobyan A.V., Karalyan Z.A. Patanatomical
description of the acute African swine fever in experiment. Veterinary medicine 97, Feodosya,
Ukrain, 2013, 97, 98-100.
Chapter in a book:
E. Arabyan, A. Kotsinyan, A. Hakobyan and Hovakim Zakaryan . African Swine Fever Virus.
Pages: 1-20.DOI: https://doi.org/10.21775/9781910190913.01 Porcine Viruses: From Pathogenesis to
Strategies for Control. Publisher: Caister Academic Press Edited by: Hovakim Zakaryan