Информация

Кандидат биологических наук, заведующая кафедрой биоинженерии, биоинформатики и молекулярной биологии Института Биомедицины и Фармации Российско-Армянского университета

Образование высшее, ЕГУ

Читаемые дисциплины генетика, молекулярная генетика, геномика и протеомика, критический анализ научной литературы, генная инженерия, мировые генетические ресурсы.

CV

Научные интересы

• Молекулярная биология
• Генетика
• Иммунология
• Психиатрия

Список основных публикаций

• Zakharyan R., Arakelyan A. NGF in psychiatric disorders: update on current findings. Chapter in: Advanced in Medicine and Biology, Nova Science Publishers, USA,
• Boyajyan A., Zakharyan R., Atshemyan S., Ghazaryan H. Chapter 5. “Biopsychology of schizophrenia: novel molecular genetic markers of cognitive dysfunction”. In: Advances in Psychology Research (Editor: A.M. Columbus), Nova Science Publishers Inc., USA, 2015, v. 110, pp. 69-124. ISBN: 978-1-63482-629-7.
• Boyajyan A., Zakharyan R., Khoyetsyan A. Chapter XI. Molecular and genetic indicators of aberrant immunity and apoptosis in schizophrenia In: Schizophrenia research: Recent advances (Editor: T. Sumiyoshi), Nova Science Publishers Inc., USA, 2012, pp. 183-240.
• Stepanyan A., Zakharyan R., Simonyan A., Tsakanova G., Arakelyan A. Involvement of polymorphisms of the nerve growth factor and its receptor encoding genes in the etiopathogenesis of ischemic stroke. BMC Medical Genetics 2018; 19(1): 33.
• Захарян Р.В., Телумян Е.Г., Геворкян А.П., Аракелян А.А. Отсутствие ассоциации полиморфизма rs6339 гена нейротрофинового рецептора тирозинкиназы типа 1 с шизофренией у армянской популяции. Медицинская генетика 2017, 16(4): 40-43.
• Malakyan M., Ayvazyan V., Manukyan G., Hovsepyan L., Arakelova E., Avetyan D., Ghazaryan H., Melkonyan A., Zakharyan R., Arakelyan A. Effects of Schiff base aromatic amino acid derivatives on antioxidant and immune system disturbances in a rat model of aflatoxin B1 induced experimental mycotoxicosis. F1000Research 2017. 6:1413, doi: 10.12688/f1000research.11756.1.
• Atshemyan S., Chavushyan A., Berberian N., Sahakyan A., Zakharyan R., Arakelyan A. Characterization of BRCA1/2 mutations in patients with family history of breast cancer in Armenia. F1000Research 2017. 6:29, 10.12688/f1000research.10434.1.
• Martirosyan G., Lyangasova O., Zakharyan R., Mashkina E., Shkurat T., Arakelyan A. Epidemiological study on the prevalence of urogenital infections in Armenia and Russia. Biological Journal of Armenia 2016, LXVIII, p.93-97.
• Boyajyan A.S., Atshemyan S.A., Zakharyan R.V. Association of schizophrenia with variations in genes encoding transcription factors. Molecular Biology (Mosk.) 2015, 49 (6):977-983.
• Boyajyan A, Zakharyan R, Atshemyan S, Chavushyan A, Mkrtchyan G. Schizophrenia-associated risk and protective variants of c-Fos encoding gene. Recent Advances in DNA and Gene Sequencing 2015 (PMID: 25706621). DOI: 10.2174/2352092209666150223113334.
• Zakharyan R., Atshemyan S., Gevorgyan A, Boyajyan A. Nerve growth factor and its receptor in schizophrenia. Biochimica et Biophysica Acta Clinical (BBA Clinical) 2014, 1:24-29, doi:10.1016/j.bbacli.2014.05.001.
• Zakharyan R., Atshemyan S., Boyajyan A. Risk and protective effects of the complexin-2 gene and gene-environment interactions in schizophrenia. Recent Advances in DNA and Gene Sequencing 2014, 8(1):30-34.
• Zakharyan R., Boyajyan A. Brain-derived neurotrophic factor blood levels are decreased in schizophrenia patients and associate with rs6265 genotypes. Clinical Biochemistry 2014, 47(12):1052-1055, doi: 10.1016/j.clinbiochem.2014.03.021.
• Zakharyan R., Boyajyan A. Inflammatory cytokine network in schizophrenia. World Journal of Biological Psychiatry 2014, 15(3):174-187.
• Arakelyan A., Zakharyan R., Hambardzumyan M., Petrkova J., Olsson M.C., Petrek M., Boyajyan A. Functional genetic polymorphisms of monocyte chemoattractant protein 1 and C-C chemokine receptor type 2 in ischemic stroke. Journal of Interferon & Cytokine Research 2014, 34(2):100-105, doi:10.1089/jir.2013.0030.
• Boyajyan A., Stepanyan A., Avetyan D., Ghazaryan H., Atshemyan S., Zakharyan R., Pirumyan K., Tsakanova G. Genetic variations associated with brain disorders: Focus on synaptic plasticity and apoptosis regulatory genes in schizophrenia, posttraumatic stress disorder and ischemic stroke. International Journal of Genetics and Genomics 2014, 2(2):19-29.
• Zakharyan R., Atshemyan S., Gevorgyan A., Boyajyan A. Synaptic plasticity regulating genes in schizophrenia. Biological Journal of Armenia 2013, 65 (Suppl. 1):150-152.
• Atshemyan S., Zakharyan R., Nersisyan L., Arakelyan A., Boyajyan A. C-C chemokine receptor type 2 gene variant as a risk factor for schizophrenia. Biological Journal of Armenia 2013, 65 (Suppl.1):39-40.
• Novoselova M., Linnik A., Sukhikh C., Prosekov A., Zakharyan R., Boyajyan A. Selection of universal primers for adulteration identification of apricot product. Biological Journal of Armenia 2013, 65 (Suppl. 1):120-121.
• Stepanyan A., Zakharyan R., Boyajyan A. The netrin G1 gene rs628117 polymorphism is associated with ischemic stroke. Neuroscience Letters 2013, 549:74-77.
• Zakharyan R.V., Boyajyan A.S. Neurotrophin family gene as potential target for schizophrenia. Electronic Journal of Natural Sciences (NAS RA) 2013; 2(21):82-86.
• Boyajyan A.S., Chavushyan A.S., Zakharyan R.V., Mkrtchyan G.M. Markers of apoptotic dysfunction in schizophrenia. Molecular biology (Moscow), 2013, 47(4):587-591.
• Boyajyan A.S., Mkrtchyan G.M., Chavushyan A.S., Zakharyan R.V., Khoyetsyan А.G., Gevorkyan A.P. The levels of annexin-A5 in the blood of patients with schizophrenia. Psychiatry (Moscow), 2013, 58(2-3).
• Zakharyan R., Petrek M., Arakelyan A., Mrazek F., Atshemyan S., Boyajyan A. Interleukin-6 promoter polymorphism and plasma levels in patients with schizophrenia. Tissue Antigens 2012, 80(2):136-142.
• Zakharyan R., Boyajyan A., Arakelyan A., Melkumova M., Mrazek F., Petrek M. Monocyte chemoattractant protein-1 in schizophrenia: -2518A/G genetic variant and protein levels in Armenian population. Cytokine 2012, 58(3):351-354.
• Zakharyan R., Khoyetsyan A., Arakelyan A., Boyajyan A., Gevorgyan A., Stahelova A., Mrazek F., Petrek M. Association of C1QB gene polymorphism with schizophrenia in Armenian population. BMC Medical Genetics 2011, 12(1):126.
• Arakelyan A., Zakharyan R., Khoyetsyan A., Poghosyan D., Aroutiounian R., Mrazek F., Petrek M., Boyajyan A. Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia. BMC Clinical Pathology 2011, 11:10.
• Zakharyan R., Boyajyan A., Arakelyan A., Gevorgyan A., Mrazek F., Petrek M. Functional variants of the genes involved in neurodevelopment and susceptibility to schizophrenia in Armenian population. Human Immunology 2011, 72(9):746-748.
• Chavushyan A., Zakharyan R., Khoyetsyan A. Protective effect of the complement component gene polymorphism in schizophrenia. Biological Journal of Armenia 2010, 62 (Suppl 1):24-27.
• Zakharyan R., Chavushyan A., Khoyetsyan A., Stahelova A., Arakelyan A., Boyajyan A., Mrazek F., Petrek M. Genetic variants of the inflammatory C-reactive protein and schizophrenia in Armenian population: A pilot study. International Journal of Immunogenetics 2010, 37(5):407-410.
• Zakharyan R., Hayrapetyan V., Karapetyan L., Arakelyan A. Association of cystatin-3 gene polymorphisms with schizophrenia. Abstracts of the 5th ECI, Amsterdam, The Netherlans, 2-5 September, 2018, p.127.
• Stepanyan A., Tsakanova G., Zakharyan R., Simonyan A., Arakelyan A. Nerve growth factor and its receptor encoding genes in ischemic stroke. FEBS Journal 2017; 284:241.doi:10.1111/febs.14174
• Atshemyan S., Arakelyan A., Zakharyan R. No association between collapsin response mediator protein gene variations and schizophrenia. European Neuropsychopharmacology 2017; 27: S13-S14.
• Zakharyan R., Chavushyan A., Hayrapetyan V., Hovhannisyan A., Khachatryan Z., Yepiskoposyan L., Arakelyan A. Analysis of genetic variants associated with antipsychotic treatment efficacy in healthy Armenian individuals. Abstracts of the 30th ECNP congress, European Neuropsychopharmacology 2017; 27, S656.
• Zakharyan R., Atshemyan S., Telumyan E., Chavushyan A., Arakelyan A. Schizophrenia and contributory genetic combinations in Armenians. European Neuropsychopharmacology 2016, 26: S169.
• Atshemyan S., Telumyan E., Arakelyan A., Zakharyan R. Association of complexin-4 gene variants with schizophrenia. European Neuropsychopharmacology 2016, 26: S189.
• Ghazaryan H., Zakharyan R., Stepanyan A., Petrek M., Arakelyan A. Genetic variations of complement factors in schizophrenia. European Journal of Immunology 2016. 46 (Suppl. 1): 547-548, DOI: 10.1002/eji.201670200
• Stepanyan A., Tsakanova G., Zakharyan R., Arakelyan A., Boyajyan A. Synaptic plasticity genes polymorphisms and ischemic stroke risk. Cerebrovascular diseases 2016, 41: 251, https://doi.org/10.1159/000446380
• Ghazaryan H., Boyajyan A., Zakharyan R., Melkonyan A., Navratilova Z., Klevcova P., Petrek M. Schizophrenia is associated with over-expression of the interleukin-2 receptor gamma gene. Frontiers in Immunolology 2013, doi: 10.3389/conf.fimmu.2013.02.00380.
• Zakharyan R., Atshemyan S., Boyajyan A. Increased levels of IL-6, TNF-a, MIF, IL-8, and MCP-1 in schizophrenia. Frontiers in Immunolology 2013, doi: 10.3389/conf.fimmu.2013.02.00354.
• Zakharyan R., Atshemyan S., Boyajyan A. Molecular biomarkers of schizophrenia: from biological signs to novel treatment targets. European Neuropsychopharmacology, 2013, 23 (Suppl. 2): S428, www.sciencedirect.com/science/article/pii/S0924977X13706771, P.3.a.011.
• Zakharyan R., Atshemyan S., Boyajyan A. The role of neuroprotein in schizophrenia pathogenesis. Journal of the Neurological Sciences 2013, 333:e335-e336,
• Zakharyan R., Atshemyan S., Boyajyan A. Altered levels of cytokine in schizophrenia. Cytokine 2012, 59(3):572-573.
• Chavushyan A., Zakharyan R., Tsakanova G., Boyajyan A. Annexin-V-1C/T apoptotic marker as a risk factor for schizophrenia. Journal of Neurochemistry 2012, 122(Suppl. 1):31.
• Zakharyan R.V., Boyajyan A.S. New candidate genes for schizophrenia disorder. Proceedings of International conference on the postgenomic technology for biomedicine-2012, Novosibirsk, Russia, Abstract book, p. 138.
• Zakharyan R., Arakelyan A., Atshemyan S., Boyajyan A. Role of chemokine gene variants in the pathogenesis of schizophrenia. Proceedings of “Genomic disorders: the genomics of rare diseases 2012” conference, 2012, Hinxton, Cambridge, UK, Abstract book, p. 59.
• Zakharyan R.V., Poghosyan D.A., Arakelyan А.А., Boyajyan A. Cytogenetic study of the complement receptor type 1 (CR1) in schizophrenia. Proceedings of IV International young scientists school on molecular genetics “Genomics and Cell Biology”, 2010, Moscow-Zvenigorod, Abstract book, pp.90-92.
• Zakharyan R., Khoyetsyan A., Chavushyan A., Arakelyan A., Boyajyan A., Stahelova A., Mrazek F., Petrek M. Polymorphisms in the CRP gene and schizophrenia in Armenian population: A pilot study. Abstracts of the XII Czech conference of DNA diagnostics, 2009, Olomouc, Czech Republic. Abstract book, p.47.
• Grigor'eva E.V., Karapetyan L.V., Malakhova A.A., Medvedev S.P., Minina J.M., Hayrapetyan V.H., Vardanyan V.S., Zakian S.M., Arakelyan A., Zakharyan R. Generation Generation of iPSCs from a Patient with the M694V Mutation in the MEFV Gene Associated with Familial Mediterranean Fever and Their Differentiation into Macrophages. International Journal of Molecular Sciences (MDPI) 2024. Accepted for publication
• Grigor'eva E.V., Malakhova A.A., Ghukasyan L., Hayrapetyan V., Atshemyan S., Vardanyan V., Zakian S.M., Zakharyan R., Arakelyan A. Generation of three induced pluripotent stem cell lines (RAUi001-A, RAUi001-B and RAUi001-C) from peripheral blood mononuclear cells of a healthy Armenian individual. Stem Cell Res. 2023;71:103147. doi: 10.1016/j.scr.2023.103147.
• Loeffler-Wirth H., Hopp L., Schmidt M., Zakharyan R., Arakelyan A., Binder H. The transcriptome and methylome of the developing and aging brain and their relations to gliomas and psychological disorders. Cells (MDPI) 2022;11(3):362. doi: 10.3390/cells11030362.
• Avetyan D, Chavushyan A, Ghazaryan H, Melkonyan A, Stepanyan A, Zakharyan R, Hayrapetyan V, Atshemyan S, Khachatryan G, Sirunyan T, Davitavyan S, Martirosyan G, Melik-Andreasyan G, Sargsyan S, Ghazazyan A, Aleksanyan N, Yin X, Arakelyan A. SARS-CoV-2 detection by extraction-free qRT-PCR for massive and rapid COVID-19 diagnosis during a pandemic in Armenia. Journal of Virology Methods. 2021;295:114199. doi: 10.1016/j.jviromet.2021.114199.
• Avetyan D., Chavushyan A., Ghazaryan H., Melkonyan A., Stepanyan A., Zakharyan R., et al. Molecular Genetic Analysis of SARS-CoV-2 Lineages in Armenia. medRxiv 2020, doi: https://doi.org/10.1101/2021.06.19.21259172
• Avetyan D., Zakharyan R., Petrek M., Arakelyan A. Leucocyte telomere length, genetic variants at the TERT gene region and risk of posttraumatic stress disorder. European Neuropsychopharmacology 2020, 31: S9-S10, doi:10.1016/j.euroneuro.2019.12.012
• Zakharyan R., Ghazaryan H., Kocourkova L., Chavushyan A., Mkrtchyan A., Zizkova V., Arakelyan A., Petrek M. Association of genetic variants of dopamine and serotonin receptors with schizophrenia. Archives of Medical Research 2020, 51(1):13-20, doi: 10.1016/j.arcmed.2019.12.011.
• Atshemyan S., Zakharyan R., Arakelyan A. Revealing the functional role of the genes and /կյproteins associated with schizophrenia. European Neuropsychopharmacology 2019, 29:S532-S533, doi.org/10.1016/J.EURONEURO.2019.09.
• Avetyan. D., Zakharyan R., Petrek M., Arakelyan A. Association between rs734194 genetic variant of nerve growth factor receptor (NGFR) and peripheral telomere length with posttraumatic stress disorder. Journal of Neural Transmission 2019, 126(11):1532. https://doi.org/10.1007/s00702-019-02095-9
• Avetyan D., Zakharyan R., Petrek M., Arakelyan A. Telomere shortening in blood leukocytes of patients with posttraumatic stress disorder. Journal of Psychiatric Research 2019, 111:83-88, doi: 10.1016/j.jpsychires.2019.01.018.

Дисциплины

• Генетика
• Геномика и протеомика
• Спецкурс 2 Мировые генетические ресурсы

Менеджеры

• Ирицян Луиза Сергоевна