Galina Hovhannisyan
Doctor of Science, Professor
About
Education
1978-1983 Faculty of Biology, Yerevan State University
Academic degree
1990 Ph.D. Thesis title: "The study of anticlastogens under the action of chemical mutagens in the cells of allergic patients and healthy donors", Yerevan State University
2013 D.Sc. Thesis title: "Localization of DNA and chromosomal damage in human cells", Yerevan State University
2017 Professor of Biology
Professional Experience
1983 - 1985 Laboratory assistant, Institute of Common Hygiene and Occupational Diseases
1985-1994 Scientist, Yerevan State Medical University, National Institute of Public Health
1994-2021 Senior Research Scientist, Laboratory of General and Molecular Genetics, Research Institute of Biology, Yerevan State University
2021 - present Leading Researcher, Laboratory of General and Molecular Genetics, Research Institute of Biology, Yerevan State University
2000 -2009 Assistant of Professor of Department of Genetics and Cytology, Faculty of Biology, Yerevan State University
2009 - 2017 Associated Professor of Department of Genetics and Cytology, Faculty of Biology, Yerevan State University
2017-present Professor of Department of Genetics and Cytology, Faculty of Biology, Yerevan State University
2017-present Professor, Russian-Armenian University
Research Fields
Genetic toxicology; ecogenetics; mutagenesis; antimutagenesis; molecular cytogenetics
Teaching Activities
Epigenetics, Genetic Toxicology, Molecular Cytogenetics, Genomics and Molecular Medicine, Genetic Analysis, Behavioral genetics, Pharmacogenetics
Grants awarded
2006-2007 DAAD research visit grant
2007-2008 DFG research visit grant
2009 DLR/BMBF research visit grant
2010-2011 DFG research visit grant
2013-2014 MES-BMBF research project
2014-2015 DAAD research visit grant
2016-2017 ANSEF (molbio-4235)
2017-2020 Ministry of Education, Science, Culture and Sports RA Science Committee, SCS-BMBF Establishment of the Armenian-German Joint Research Laboratory for development of research and educational programs in the field of molecular cytogenetics in Armenia., Armenia-Germany
2018-2020 Ministry of Education, Science, Culture and Sports RA Science Committee (18T-1F039), Development of CRISPR-Cas9 genome editing technology for sensitization of cancer cells to anticancer drugs, SCS, Yerevan, Armenia
2021-2026 Ministry of Education, Science, Culture and Sports RA Science Committee, (21AG‐1F068), Development of new genetic markers of SARS-CoV-2-associated genomic instability and approaches to its regulation
1978-1983 Faculty of Biology, Yerevan State University
Academic degree
1990 Ph.D. Thesis title: "The study of anticlastogens under the action of chemical mutagens in the cells of allergic patients and healthy donors", Yerevan State University
2013 D.Sc. Thesis title: "Localization of DNA and chromosomal damage in human cells", Yerevan State University
2017 Professor of Biology
Professional Experience
1983 - 1985 Laboratory assistant, Institute of Common Hygiene and Occupational Diseases
1985-1994 Scientist, Yerevan State Medical University, National Institute of Public Health
1994-2021 Senior Research Scientist, Laboratory of General and Molecular Genetics, Research Institute of Biology, Yerevan State University
2021 - present Leading Researcher, Laboratory of General and Molecular Genetics, Research Institute of Biology, Yerevan State University
2000 -2009 Assistant of Professor of Department of Genetics and Cytology, Faculty of Biology, Yerevan State University
2009 - 2017 Associated Professor of Department of Genetics and Cytology, Faculty of Biology, Yerevan State University
2017-present Professor of Department of Genetics and Cytology, Faculty of Biology, Yerevan State University
2017-present Professor, Russian-Armenian University
Research Fields
Genetic toxicology; ecogenetics; mutagenesis; antimutagenesis; molecular cytogenetics
Teaching Activities
Epigenetics, Genetic Toxicology, Molecular Cytogenetics, Genomics and Molecular Medicine, Genetic Analysis, Behavioral genetics, Pharmacogenetics
Grants awarded
2006-2007 DAAD research visit grant
2007-2008 DFG research visit grant
2009 DLR/BMBF research visit grant
2010-2011 DFG research visit grant
2013-2014 MES-BMBF research project
2014-2015 DAAD research visit grant
2016-2017 ANSEF (molbio-4235)
2017-2020 Ministry of Education, Science, Culture and Sports RA Science Committee, SCS-BMBF Establishment of the Armenian-German Joint Research Laboratory for development of research and educational programs in the field of molecular cytogenetics in Armenia., Armenia-Germany
2018-2020 Ministry of Education, Science, Culture and Sports RA Science Committee (18T-1F039), Development of CRISPR-Cas9 genome editing technology for sensitization of cancer cells to anticancer drugs, SCS, Yerevan, Armenia
2021-2026 Ministry of Education, Science, Culture and Sports RA Science Committee, (21AG‐1F068), Development of new genetic markers of SARS-CoV-2-associated genomic instability and approaches to its regulation
List of publications
- 1. Simonyan A, Gabrielyan B, Minasyan S, Hovhannisyan G, Aroutiounian R. Genotoxicity of Water Contaminants from the Basin of Lake Sevan, Armenia Evaluated by the Comet Assay in Gibel Carp (Carassius auratus gibelio) and Tradescantia Bioassays. Bull Environ Contam Toxicol. 2016 Mar;96(3):309-13. doi: 10.1007/s00128-015-1720-4. Epub 2016 Jan 7. PubMed PMID: 26739952.
- 2. Hovhannisyan G, Aroutiounian R, Babayan N, Harutyunyan T, Liehr T. Comparative analysis of individual chromosome involvement in micronuclei induced by mitomycin C and bleomycin in human leukocytes. Mol Cytogenet. 2016 Jun 21;9:49. doi: 10.1186/s13039-016-0258-4. eCollection 2016. PubMed PMID: 27330564; PubMed Central PMCID: PMC4915088.
- 3. Harutyunyan T, Babayan N, Aroutiounian R, Hovhannisyan G. Cell viability and DNA damage in MRC5 and HeLa cell lines after histone H1 knockout by CRISPR-Cas9 genome editing technology. PROCEEDINGS OF THE YEREVAN STATE UNIVERSITY, Chemistry and Biology 2016, № 3, p. 64–66
- 4. Babayan N, Hovhannisyan G, Grigoryan B, Grigoryan R, Sarkisyan N, Tsakanova G, Haroutiunian S, Aroutiounian R. Dose-rate effect of ultrashort electron beam radiation on DNA damage and repair in vitro. J Radiat Res. 2017 Nov 1;58(6):894-897. doi: 10.1093/jrr/rrx035. PubMed PMID: 28992052; PubMed Central PMCID: PMC5737585.
- 5. Hovhannisyan G, Harutyunyan T, Liehr T. PART V. INTERPHASE FISH. Micronucleus FISH, p. 379-385. Fluorescence in situ Hybridization (FISH) – Application Guide, T. Liehr (Editor), 2nd Ed., Springer, Berlin, 2017, ISBN: 978-3662529577.
- 6. Hovhannisyan G, Aroutiounian R PART V. INTERPHASE FISH. Comet-FISH, p. 373-37. Fluorescence in situ Hybridization (FISH) – Application Guide, T. Liehr (Editor), 2nd Ed., Springer, Berlin, 2017, ISBN: 978-3662529577.
- 7. Simonyan A, Hovhannisyan G, Sargsyan A, Arakelyan M, Minasyan S, Aroutiounian R. DNA damage and micronuclei in parthenogenetic and bisexual Darevskia rock lizards from the areas with different levels of soil pollution. Ecotoxicol Environ Saf. 2018 Jun 15;154:13-18. doi: 10.1016/j.ecoenv.2018.02.025. Epub 2018 Feb 22. PubMed PMID: 29453160.
- 8. Hovhannisyan, G., Harutyunyan, T. & Aroutiounian, R. Micronuclei and What They Can Tell Us in Cytogenetic Diagnostics. Curr Genet Med Rep (2018) 6: 144. https://doi.org/10.1007/s40142-018-0149-6
- 9. Simonyan A.E., Sargsyan A.A., Hovhannisyan G.G., Badalyan N.S. , Minasyan S.H. Application of Crayfish Astacus Leptodactylus for the Analysis of Water Genotoxicity in the Lake Sevan Basin. J. Water Chem. Technol. (2018) 40: 367–369.
- 10. Babayan N, Grigoryan B, Hovhannisyan G, Tadevosyan G, Khondkaryan L, Grigoryan R, Sarkisyan N, Aroutiounian R. Gender differences in DNA damage/repair after laser-generated ultrafast electron beam irradiation. International Journal of Radiology & Radiation Therapy, 2018, Volume 5 Issue 2, p 85-86.
- 11. Harutyunyan T, Hovhannisyan G, Sargsyan A, et al. Analysis of copy number variations induced by ultrashort electron beam radiation in human leukocytes in vitro. Mol Cytogenet. 2019;12:18. Published 2019 May 16. doi:10.1186/s13039-019-0433-5
- 12. Harutyunyan T, Hovhannisyan G, Sargsyan A, et al. Analysis of copy number variations induced by ultrashort electron beam radiation in human leukocytes in vitro. Mol Cytogenet. 2019;12:18. Published 2019 May 16. doi:10.1186/s13039-019-0433-5
- 13. Sargsyan A, Simonyan A, Hovhannisyan G, Arakelyan M, Aroutiounian R. Application of the comet assay, micronucleus test and global DNA methylation analysis in Darevskia lizards as a sentinel organism for genotoxic monitoring of soil pollution. Mutat Res. 2019 Jun;842:117-124. doi: 10.1016/j.mrgentox.2018.10.005. Epub 2018 Oct 25. PubMed PMID: 31255219.
- 14. Hovhannisyan G, Harutyunyan T, Aroutiounian R, Liehr T. DNA Copy Number Variations as Markers of Mutagenic Impact. Int J Mol Sci. 2019;20(19):4723. Published 2019 Sep 24. doi:10.3390/ijms20194723
- 15. Harutyunyan TA, Hovhannisyan GG, Sargsyan AA, Liehr T, Al-Rikabi AH, Aroutiounian RM. Identification of cytogenetically visible mtDNA in interphase nuclei of human blood lymphocytes exposed to doxorubicin. PROCEEDINGS OF THE YEREVAN STATE UNIVERSITY. 2020, 54(1), p. 63–67
- 16. Harutyunyan T, Al-Rikabi A, Sargsyan A, Hovhannisyan G, Aroutiounian R, Liehr T. Doxorubicin-Induced Translocation of mtDNA into the Nuclear Genome of Human Lymphocytes Detected Using a Molecular-Cytogenetic Approach. Int J Mol Sci. 2020 Oct 17;21(20):7690. doi: 10.3390/ijms21207690. PMID: 33080837; PMCID: PMC7589397.