About
Date of birth: March 10, 1951, Kamo, Armenia
2002-present Member of the Scientific Council of the Institute of Organic Chemistry (Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NAS RA).
2002-present Member of the Specialized Scientific Council No. 010 of the Institute of Organic Chemistry (Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NAS RA)- on conferring scientific degrees in the field of organic, bioorganic chemistry and chemistry of polymers.
2008-present Member of the Scientific Council of the Russian-Armenian (Slavonic) State University.
Title: Sc. D., Professor of Chemistry
Current institutional affiliation: Professor at the Institute of Biomedicine and Pharmacy of the Russian-Armenian (Slavonic) State University.
Previous institutional affiliations:
1973 Graduated from the Yerevan University with honors
1973-1977 Post-graduate at the Chemical Department of the Moscow State University named after M.Lomonosov (Research leaders - Prof. A.N.Kost, R.S.Sagitullin)
1978 Defended a thesis for a Candidate’s degree at the Moscow State University on the theme: “Transformations of pyrimidine ring under the influence of nucleophyles”.
1977-1982 Researcher at the Institute of Fine Organic Chemistry named after A.L.Mndzoyan of the Academy of Sciences of Armenia (worked on synthesis of biologically active compounds in the series of pyrimidines, pteridines, furo- and thieno[2,3-d]pyrimidines).
1982 - to date Yerevan State Institute of Economy (Armenia).
1982-1992 Senior researcher
1992-1995 Leading researcher
1995-2000 Research leader of the scientific team of ogranic synthesis.
2001-to date Team leader at the Institute of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NAS RA.
2005-to date Professor at the Medical-Biological Faculty (Institute of Biomedicine and Pharmacy) of the Russian-Armenian (Slavonic) State University.
Awards:
1993 Won the individual grant of the International Science Foundation.
1994-1995 Long-term research grant of the International Science Foundation.
Title: “Synthesis of Pyrimidine Derivatives and Studies of Izomeriza-tional Recyclization of Mono- and Bicyclic Pyrimidine Systems under the influence of Nucleohpylic agents”.
1992-1995 Award # 92-1295 Ministry of Economy of Armenia. “Synthesis of potentially physiologically active compounds based on substituted pyrimidines and lactones”.
1996-1999 Award # 96-559 of the State centralized financing of the Republic of Armenia. Theme: “Interaction of multifunctional substituted lactones with nucleophiles, research of pyrimidine system rearrangements with a quarternized nitrogen atom, revealing of phisiologically active compounds in the series of reaction products”.
2000-2003 Award # ICA 2-2000-10002 “PESTICIDES”, V. Dovlatyan (PI), G. Danagulyan (Manager of the project)- prof. A.Namor (UK). Copernicus-2 “Development of Methods for the Remediation of Pesticides”
2002-2004 Award # 0471 Ministry of Education and Science of Armenia
Research of some structural and electronic factors affecting isomerizational recyclization of pyrimidinium salts.
2003-2004 Award # CH 090 02/BGP 12040, Danagulyan G.G. (PI) - Katritzky A.R. (PI) US Civilian Research and Development Foundation (CRDF) and National Foundation of Science and Advanced Technologies (NFSAT) “Introduction of pharmacophore groups into biogenic pyridines by pyrimidine-recyclizations”.
2005-2007 Award # 0543 Ministry of Education and Science of Armenia “Research of new nucleophilic rearrangements proceeding with breakage of a pyrimidine ring”.
2005-2007 Award # US CRDF - No. ARB2-2640-YE-05, – “Genotoxic and antineoplastic effects of bridged nitrogen atom-containing pyrimidines and their acyclic adducts”– Danagulyan G.G. (PI)–prof. Gewirtz D.A. (Virginia University, USA).
2013-2015 Award # 13RF-087 “Transformation of π-electron-deficient heterocycles by action of the nucleophilic agents”. Danagulyan G.G.–Chupakhin O.N. (RF2013-2015 Award # 13-1D334 “Pyrimidine-based syntheses of bis-heteroaryl systems for producing selective chemosensors of metal cations”
2018-2020 Award #18T-1D249 Ministry of Education and Science of Armenia “Synthesis of biologically active π-conjugated azaheterocycles and search in their series for chemosensors for explosives”
2021-2022 Award # 20RF-138 “Unannelated tetrazolylpyrimidines and similar “hybrid” heterocyclic systems: synthesis, structure and antiviral activity.” Danagulyan G.G.–prof. Ostrovskii V.A.(RF).
Publications: Author of more than 300 publications on chemistry of pyrimidine (Tetrahedron Lett., Heterocycles, J. Heterocyclic Chemistry, Chemistry of Heterocyclic Compounds, Pharmaceutical Chemistry Journal, Cytology and Genetics, Neurochemistry, Heterocyc. Comm., Russ.J. of Organic Chemistry, etc.), including 7 author’s certificates on synthesis and biological activity of compounds (not for publication).
Prof. Gevorg Danagulyan has discovered new transformations of pyrimidines into compounds of a pyridine series under the action of nucleophiles.
Prof. Gevorg Danagulyans team is concerned with the research of nucleophilic rearrangements of pyrimidine systems, in particular, those of the Kost-Sagitullin (N-C recyclization), Dimroth (N-N recyclization) rearrangements and C-C-recyclizations. In the course of these studies the rearrangement of 1,2-dialkylpyrimidinium salts proceeding with intrusion of the amine reagent fragment into the molecule of the pyridine derivative formed as a result of the recyclization has been discovered. It is shown that carrying out the reactions under the action of various biogenic and pharmacophore-containing amines makes it possible to purposefully synthesize derivatives of nicotinic acid and nicotinamide containing in position 2 fragment of the reacting biogenic or bioactive amine. The last years research resulted in finding new, not described in the literature, recyclizational pyrimidine transformations. These includes the rearrangement of 1,2-dialkylpyrimidinium iodides into derivatives of pyrazolo[1,5-a]pyrimidine proceeding under the action of carboxylic acids hydrazides at the expense of the pyrimidine ring opening and introduction of the reagent fragment into the reaction product.
Candidate of Chemical Sciences (Ph.D., Chemistry) – 1978, Moscow State University.
Sc. D., Professor of Chemistry – 2000, Institute of Organic Chemistry of the Academy of Sciences of Armenia.
Corresponding Member of Armenian National Academy of Science (2010).
Member of Editorial Board:
- International Journal “Chemistry of Heterocyclic Compounds” (2009-2016),
- Executive editor of “Chemical Journal of Armenia”(2007-2021),
- Editor-in-chief of “Chemical Journal of Armenia” ( 2021).
- Member of International Editorial Board “Russian J. of Chemistry and Chemical Technology” (2012-present).
- Executive editor of Journal “In the World of Science” .
2002-present Member of the Scientific Council of the Institute of Organic Chemistry (Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NAS RA).
2002-present Member of the Specialized Scientific Council No. 010 of the Institute of Organic Chemistry (Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NAS RA)- on conferring scientific degrees in the field of organic, bioorganic chemistry and chemistry of polymers.
2008-present Member of the Scientific Council of the Russian-Armenian (Slavonic) State University.
Title: Sc. D., Professor of Chemistry
Current institutional affiliation: Professor at the Institute of Biomedicine and Pharmacy of the Russian-Armenian (Slavonic) State University.
Previous institutional affiliations:
1973 Graduated from the Yerevan University with honors
1973-1977 Post-graduate at the Chemical Department of the Moscow State University named after M.Lomonosov (Research leaders - Prof. A.N.Kost, R.S.Sagitullin)
1978 Defended a thesis for a Candidate’s degree at the Moscow State University on the theme: “Transformations of pyrimidine ring under the influence of nucleophyles”.
1977-1982 Researcher at the Institute of Fine Organic Chemistry named after A.L.Mndzoyan of the Academy of Sciences of Armenia (worked on synthesis of biologically active compounds in the series of pyrimidines, pteridines, furo- and thieno[2,3-d]pyrimidines).
1982 - to date Yerevan State Institute of Economy (Armenia).
1982-1992 Senior researcher
1992-1995 Leading researcher
1995-2000 Research leader of the scientific team of ogranic synthesis.
2001-to date Team leader at the Institute of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NAS RA.
2005-to date Professor at the Medical-Biological Faculty (Institute of Biomedicine and Pharmacy) of the Russian-Armenian (Slavonic) State University.
Awards:
1994-1995 Long-term research grant of the International Science Foundation.
Title: “Synthesis of Pyrimidine Derivatives and Studies of Izomeriza-tional Recyclization of Mono- and Bicyclic Pyrimidine Systems under the influence of Nucleohpylic agents”.
1992-1995 Award # 92-1295 Ministry of Economy of Armenia. “Synthesis of potentially physiologically active compounds based on substituted pyrimidines and lactones”.
1996-1999 Award # 96-559 of the State centralized financing of the Republic of Armenia. Theme: “Interaction of multifunctional substituted lactones with nucleophiles, research of pyrimidine system rearrangements with a quarternized nitrogen atom, revealing of phisiologically active compounds in the series of reaction products”.
1999 Award # of the US CRDF (U.S. Civilian Research and Development Foundation for the Independent States of the Former Soviet Union CRDF) has been conferred jointly with the Alan R. Katritzky (USA) for the project “Novel Methodology for Pyridine Ring Synthesis”.
2000-2001 Award # 00-405 of the State centralized financing of the Republic of Armenia. Theme: “Introduction of pharmacofore groups into a pyridine ring by enamine rearrangement of pyrimidines containing a quarternized nitrogen atom as well as by interaction of lactones with nucleophilic reagents”. 2000-2003 Award # ICA 2-2000-10002 “PESTICIDES”, V. Dovlatyan (PI), G. Danagulyan (Manager of the project)- prof. A.Namor (UK). Copernicus-2 “Development of Methods for the Remediation of Pesticides”
2002-2004 Award # 0471 Ministry of Education and Science of Armenia
Research of some structural and electronic factors affecting isomerizational recyclization of pyrimidinium salts.
2003-2004 Award # CH 090 02/BGP 12040, Danagulyan G.G. (PI) - Katritzky A.R. (PI) US Civilian Research and Development Foundation (CRDF) and National Foundation of Science and Advanced Technologies (NFSAT) “Introduction of pharmacophore groups into biogenic pyridines by pyrimidine-recyclizations”.
2005-2007 Award # 0543 Ministry of Education and Science of Armenia “Research of new nucleophilic rearrangements proceeding with breakage of a pyrimidine ring”.
2005-2007 Award # US CRDF - No. ARB2-2640-YE-05, – “Genotoxic and antineoplastic effects of bridged nitrogen atom-containing pyrimidines and their acyclic adducts”– Danagulyan G.G. (PI)–prof. Gewirtz D.A. (Virginia University, USA).
2013-2015 Award # 13RF-087 “Transformation of π-electron-deficient heterocycles by action of the nucleophilic agents”. Danagulyan G.G.–Chupakhin O.N. (RF2013-2015 Award # 13-1D334 “Pyrimidine-based syntheses of bis-heteroaryl systems for producing selective chemosensors of metal cations”
2018-2020 Award #18T-1D249 Ministry of Education and Science of Armenia “Synthesis of biologically active π-conjugated azaheterocycles and search in their series for chemosensors for explosives”
2021-2022 Award # 20RF-138 “Unannelated tetrazolylpyrimidines and similar “hybrid” heterocyclic systems: synthesis, structure and antiviral activity.” Danagulyan G.G.–prof. Ostrovskii V.A.(RF).
Publications: Author of more than 300 publications on chemistry of pyrimidine (Tetrahedron Lett., Heterocycles, J. Heterocyclic Chemistry, Chemistry of Heterocyclic Compounds, Pharmaceutical Chemistry Journal, Cytology and Genetics, Neurochemistry, Heterocyc. Comm., Russ.J. of Organic Chemistry, etc.), including 7 author’s certificates on synthesis and biological activity of compounds (not for publication).
Prof. Gevorg Danagulyan has discovered new transformations of pyrimidines into compounds of a pyridine series under the action of nucleophiles.
Prof. Gevorg Danagulyans team is concerned with the research of nucleophilic rearrangements of pyrimidine systems, in particular, those of the Kost-Sagitullin (N-C recyclization), Dimroth (N-N recyclization) rearrangements and C-C-recyclizations. In the course of these studies the rearrangement of 1,2-dialkylpyrimidinium salts proceeding with intrusion of the amine reagent fragment into the molecule of the pyridine derivative formed as a result of the recyclization has been discovered. It is shown that carrying out the reactions under the action of various biogenic and pharmacophore-containing amines makes it possible to purposefully synthesize derivatives of nicotinic acid and nicotinamide containing in position 2 fragment of the reacting biogenic or bioactive amine. The last years research resulted in finding new, not described in the literature, recyclizational pyrimidine transformations. These includes the rearrangement of 1,2-dialkylpyrimidinium iodides into derivatives of pyrazolo[1,5-a]pyrimidine proceeding under the action of carboxylic acids hydrazides at the expense of the pyrimidine ring opening and introduction of the reagent fragment into the reaction product.
Scientific interests
- Synthesis of biologically active compounds from the series of nitrogencontaining heterocycles (pyrimidine, pyridine, pyrazole, pteridine), as well as derivatives of aminoacids, oximes, thioacids, hydrazides, connected with the pyrimidine nucleus.
- Research of new reactions of mono- and bicyclic pyrimidines with nucleophilic reagents.