About
|
Titles 1978 1993 |
Ph.D. in Biology Doctor Sciantiarum |
|
Trainings&Lecturing activity 1997-present |
Professor of Bioinformatics at Russian-Armenian University. In 2006 established and teaches the first course of Bioinformatics in Armenia, also teaches Structural Bioinformatics, Drug Design, has been Mentor of 8 PhD students. |
| Professional Experience | |
| 1996-present | Head of Laboratory of Organ Specific Proteins at the Institute of Molecular Biology of the National Academy of Sciences of Armenia |
| 1993-1996 | Associated Professor at the Institute of Biochemistry and Diabetology, Geneva, Switzerland |
List of publications
- 1. Hakobyan, D. and Nazaryan, K., 2006. Investigation of interaction between enolase and phosphoglycerate mutase using molecular dynamics simulation. Journal of Biomolecular Structure and Dynamics, 23(6), pp.625-633.
- 2. Hakobyan, D. and Nazaryan, K., 2006. Molecular dynamics simulation of interactions in glycolytic enzymes. Biochemistry (Moscow), 71(4), pp.370-375.
- 3. Hakobyan, D. and Nazaryan, K., 2010. Molecular dynamics study of interaction and substrate channeling between neuron‐specific enolase and B‐type phosphoglycerate mutase. Proteins: Structure, Function, and Bioinformatics, 78(7), pp.1691-1704.
- 4. Hakobyan D., Varzhabetyan L., Nazaryan K. Molecular dynamics of ạ-tubulin and indibulin interaction. The New Armenian Medical Journal, 2010, 4 (1), 55-56.
- 5. Varzhabetyan, L.R., Glazachev, D.V. and Nazaryan, K.B., 2012. Molecular dynamics simulation study of tubulin dimer interaction with cytostatics. Molecular Biology, 46(2), pp.316-321.
- 6. Arakelov G.G., Jahangiryan S.G., Nazaryan K.B. 2013. Influence of M694I, M695R, V744S mutations on B30.2 teriary structure and its interaction with caspase-1. Biological Journal of Armenia, 65 (Suppl.1), pp.33-34.
- 7. Arakelov, G.G., Osipov, O.V. and Nazaryan, K.B., 2015. Effects of M680I and M694V pyrin mutations on the tertiary structure of domain B30. 2 and its interaction with caspase-1: In silico analysis. Molecular Biology, 49(5), pp.736-741.
- 8. Sahakyan, H.K., Arakelov, G.G., Nazaryan, K.B., 2016. Effect of mutations and phosphorylation on pyrin structure. Biological Journal of Armenia, Volume 68, Issue 3, pp. 76-80.
- 9. Sahakyan, H.K., Arakelov, G.G. and Nazaryan, K.B., 2018. In silico Search for Tubulin Polymerization Inhibitors. Molecular Biology, 52(4), pp.604-608.
- 10. Arabyan, E., Hakobyan, A., Kotsinyan, A., Karalyan, Z., Arakelov, V., Arakelov, G., Nazaryan, K., Simonyan, A., Aroutiounian, R., Ferreira, F. and Zakaryan, H., 2018. Genistein inhibits African swine fever virus replication in vitro by disrupting viral DNA synthesis. Antiviral research, 156, pp.128-137.
- 11. Arakelov, G., Arakelov, V. and Nazaryan, K., 2018. Complex formation dynamics of native and mutated pyrin's B30. 2 domain with caspase‐1. Proteins: Structure, Function, and Bioinformatics, 86(6), pp.676-683.
- 12. Sahakyan, H., Abelyan, N., Arakelov, V., Arakelov, G. and Nazaryan, K., 2019. In silico study of colchicine resistance molecular mechanisms caused by tubulin structural polymorphism. PloS one, 14(8), p.e0221532.
- 13. Hakobyan, A., Arabyan, E., Kotsinyan, A., Karalyan, Z., Sahakyan, H., Arakelov, V., Nazaryan, K., Ferreira, F. and Zakaryan, H., 2019. Inhibition of African swine fever virus infeAction by genkwanin. Antiviral research, 167, pp.78-82.
- 14. Harutyun K. Sahakyan, Karen B. Nazaryan, Arcady R. Mushegian, and Irina N. Sorokina. Energy-dependent protein folding: modeling how a protein-folding machine may work. F1000Research 2021, 10:3 Last updated: 29 MAR 2021, PMID: 33633838
- Samvel Sirakanyan,Erik Arabyan,Astghik Hakobyan,Tamara Hakobyan,Garri Chilingaryan,Harutyun SahakyanORCID Icon,Arsen Sargsyan,Grigor Arakelov,Karen Nazaryan,Roza Izmailyan,Liana Abroyan,Zaven Karalyan,Elina Arakelova,Elmira Hakobyan,Anush Hovakimyan,Andre Serobian,Marco Neves,João Ferreira,Fernando Ferreira &Hovakim Zakaryan A new microtubule-stabilizing agent shows potent antiviral effects against African swine fever virus with no cytotoxicity. Pages 783-796 | Received 24 Sep 2020, Accepted 09 Mar 2021, Accepted author version posted online: 12 Mar 2021, Published online: 25 Apr 2021