Nelly Babayan
PhD
About
EDUCATION
Ph.D. Genetics and Cytology, Yerevan State University, Armenia 2007-2011
M.S. Biology, Yerevan State University, Armenia 2004-2006
B.S. Biology, Yerevan State University, Armenia 2000-2004
EMPLOYMENT AND PROFESSIONAL EXPERIENCE
Senior Lecturer
Department of Bioengineering. Bioinformatics and Molecular Biology
Russian - Armenian University, Armenia Sept. 2018 – present
Head of the laboratory
Laboratory of Cell Technologies,
Institute of Molecular Biology NAS RA, Armenia Sept. 2013- Present
Assistant professor
Department of Genetics and Cytology,
Yerevan State University, Armenia Sept. 2006 – Present
PREVIOUS EMPLOYMENT AND PROFESSIONAL EXPERIENCE
Visiting researcher, Institute for Pharmacology and Toxicology,
Julius Maximilian University of Würzburg, Germany Nov.2019 – Dec. 2019
Visiting researcher, Institute for Medical Physics and Biophysics,
Leipzig University, Germany Aug. 2016- Sept. 2016
Visiting researcher, Institute for Pharmacology and Toxicology,
Julius Maximilian University of Würzburg, Germany Aug.2015 – Nov. 2015
Invited Lecturer, Department of Biology,
Khon Kaen University, Thailand May 2015 – June 2015
Invited Lecturer, Department of Biology,
Khon Kaen University, Thailand Apr. 2014 – May 2014
Visiting researcher, Center for Molecular Cytogenetics,
Institute of Human Genetics, Jena, Germany Jan. 2014- Mar. 2014
Visiting researcher, Laboratory of Radiation Biology,
Joint Institute for Nuclear Research, Dubna, Russia Sept. 2009 – Dec. 2009
Research Scientist, Laboratory of Cytology,
Institute of Molecular Biology NAS RA, Armenia Jan. 2008 – Sept. 2013
HONORS/AWARDS
Tempus Scholarship
University of L'Aquila, Italy
Training on Distant Learning in Biomedical Science 2010
“The best oral presentation award”
International Young Scientists Conference
“Perspectives for Development of Molecular and Cellular Biology” 2008
FDESH “Friendship” scholarship
For Excellence in Education 2004
RESEARCH GRANTS (Principal investigator -PI or Participant- Pt)
State Committee of Science MES RA (20TTCG-1F004) (PI) 2020-2023
Title: Application of deep neural network algorithms as a tool for in silico prediction of small molecules metabolism and toxicity
Российский научный фонд (19-14-00151) (Pt) 2019-2022
Title: Молекулярные и клеточные эффекты ультракороткого импульсного излучения
COST European Cooperation in Science and Technology (CA18111) (Pt) 2019-2023
Title: Genome editing in plants - a technology with transformative potential.
State Committee of Science MES RA (18AA-010) 2018-2020
Title: Ընտրված դեղաբույսերի սիներգիկ հակաբորբոքային ազդեցության մոլեկուլային մեխանիզմների in vitro ուսումնասիրություն և արտադրանքի թողարկման առաջարկությունների մշակում
Bundesministerium für Bildung und Forschung (BMBF_CapolArm) (PI) 2017-2019
Title: Epidemiological study and risk factors of acute leukemia incidence in Armenia
State Committee of Science MES RA (17A-1F008) (PI) 2017-2019
Title: Efficiency of molecular-genetic and epigenetic changes induction by ultrafast electron irradiation in human tumor cells
Armenian National Science and Education Fund (Molbio-4551) (PI) 2017-2018
Title: The DNA damage response pathway alterations in human myeloid leukemia cells
State Committee of Science MES RA (16YR-1F052) (PI) 2016-2018
Title: The epigenetic alterations of DNA-repair systems and their targeting via RNA-interference in cancer cells
DAAD scholarship Research Stay for Academics and Scientists (5001559) (PI) 2015
Title: Epigenetic effects of Ochratoxin A and Aflatoxin B mycotoxins in neuronal cell lines
State Committee of Science MES RA (SCS_14AR 1f06) (Pt) 2014-2016
Title: Study of molecular-genetic effects of ultrafast radiation SCS and Bundesministerium für Bildung und Forschung (12GE-004) (Pt) 2013-2015
Title: Comparative analysis of individual chromosome involvement in micronuclei induced by mitomycin C
International Science and Technology Center (#A-2116) (Pt) 2014-2016
Title: Schiff base cyclic amino acid derivatives for chemoprotection against damaging action of mycotoxins
International Science and Technology Center (#A-2115) (Pt) 2014-2016
Title: Development in iron biodegradable stents: Fe-stent, polymer-coated, and drug eluting stents
International Science and Technology Center (#A-1962) (Pt) 2011-2014
Title: Development of Zinc Oxide Composites of Antitumor Drugs and Antitumor Compounds with High Antitumor Activity and Low Toxicity
International Science and Technology Center (#A-1701) (Pt) 2010-2012
Title: Proline-rich polypeptides and hematopoietic regulation
U.S. Civilian And Development Foundation (ECSP-09-36_SASP) (Pt) 2009-2010
Title: Synthesis of asymmetrically meso-substituted cationic (metallo)porphyrins and investigation of their biological activity at cellular level
Armenian National Science and Education Fund (NS-BIOTECH-1387) (Pt) 2008-2009
Title: Synthesis of New Water-Soluble (Metallo)Porphyrins and Investigation of Their Anticancer Activities in vitro and in vivo
National Foundation of Science and Advanced Technologies (GRASP 29/06) (Pt) 2006-2007
Title: The cytotoxic action of new Ag-porphyrin as a potential chemotherapeutic agent
Ph.D. Genetics and Cytology, Yerevan State University, Armenia 2007-2011
M.S. Biology, Yerevan State University, Armenia 2004-2006
B.S. Biology, Yerevan State University, Armenia 2000-2004
EMPLOYMENT AND PROFESSIONAL EXPERIENCE
Senior Lecturer
Department of Bioengineering. Bioinformatics and Molecular Biology
Russian - Armenian University, Armenia Sept. 2018 – present
Head of the laboratory
Laboratory of Cell Technologies,
Institute of Molecular Biology NAS RA, Armenia Sept. 2013- Present
Assistant professor
Department of Genetics and Cytology,
Yerevan State University, Armenia Sept. 2006 – Present
PREVIOUS EMPLOYMENT AND PROFESSIONAL EXPERIENCE
Visiting researcher, Institute for Pharmacology and Toxicology,
Julius Maximilian University of Würzburg, Germany Nov.2019 – Dec. 2019
Visiting researcher, Institute for Medical Physics and Biophysics,
Leipzig University, Germany Aug. 2016- Sept. 2016
Visiting researcher, Institute for Pharmacology and Toxicology,
Julius Maximilian University of Würzburg, Germany Aug.2015 – Nov. 2015
Invited Lecturer, Department of Biology,
Khon Kaen University, Thailand May 2015 – June 2015
Invited Lecturer, Department of Biology,
Khon Kaen University, Thailand Apr. 2014 – May 2014
Visiting researcher, Center for Molecular Cytogenetics,
Institute of Human Genetics, Jena, Germany Jan. 2014- Mar. 2014
Visiting researcher, Laboratory of Radiation Biology,
Joint Institute for Nuclear Research, Dubna, Russia Sept. 2009 – Dec. 2009
Research Scientist, Laboratory of Cytology,
Institute of Molecular Biology NAS RA, Armenia Jan. 2008 – Sept. 2013
HONORS/AWARDS
Tempus Scholarship
University of L'Aquila, Italy
Training on Distant Learning in Biomedical Science 2010
“The best oral presentation award”
International Young Scientists Conference
“Perspectives for Development of Molecular and Cellular Biology” 2008
FDESH “Friendship” scholarship
For Excellence in Education 2004
RESEARCH GRANTS (Principal investigator -PI or Participant- Pt)
State Committee of Science MES RA (20TTCG-1F004) (PI) 2020-2023
Title: Application of deep neural network algorithms as a tool for in silico prediction of small molecules metabolism and toxicity
Российский научный фонд (19-14-00151) (Pt) 2019-2022
Title: Молекулярные и клеточные эффекты ультракороткого импульсного излучения
COST European Cooperation in Science and Technology (CA18111) (Pt) 2019-2023
Title: Genome editing in plants - a technology with transformative potential.
State Committee of Science MES RA (18AA-010) 2018-2020
Title: Ընտրված դեղաբույսերի սիներգիկ հակաբորբոքային ազդեցության մոլեկուլային մեխանիզմների in vitro ուսումնասիրություն և արտադրանքի թողարկման առաջարկությունների մշակում
Bundesministerium für Bildung und Forschung (BMBF_CapolArm) (PI) 2017-2019
Title: Epidemiological study and risk factors of acute leukemia incidence in Armenia
State Committee of Science MES RA (17A-1F008) (PI) 2017-2019
Title: Efficiency of molecular-genetic and epigenetic changes induction by ultrafast electron irradiation in human tumor cells
Armenian National Science and Education Fund (Molbio-4551) (PI) 2017-2018
Title: The DNA damage response pathway alterations in human myeloid leukemia cells
State Committee of Science MES RA (16YR-1F052) (PI) 2016-2018
Title: The epigenetic alterations of DNA-repair systems and their targeting via RNA-interference in cancer cells
DAAD scholarship Research Stay for Academics and Scientists (5001559) (PI) 2015
Title: Epigenetic effects of Ochratoxin A and Aflatoxin B mycotoxins in neuronal cell lines
State Committee of Science MES RA (SCS_14AR 1f06) (Pt) 2014-2016
Title: Study of molecular-genetic effects of ultrafast radiation SCS and Bundesministerium für Bildung und Forschung (12GE-004) (Pt) 2013-2015
Title: Comparative analysis of individual chromosome involvement in micronuclei induced by mitomycin C
International Science and Technology Center (#A-2116) (Pt) 2014-2016
Title: Schiff base cyclic amino acid derivatives for chemoprotection against damaging action of mycotoxins
International Science and Technology Center (#A-2115) (Pt) 2014-2016
Title: Development in iron biodegradable stents: Fe-stent, polymer-coated, and drug eluting stents
International Science and Technology Center (#A-1962) (Pt) 2011-2014
Title: Development of Zinc Oxide Composites of Antitumor Drugs and Antitumor Compounds with High Antitumor Activity and Low Toxicity
International Science and Technology Center (#A-1701) (Pt) 2010-2012
Title: Proline-rich polypeptides and hematopoietic regulation
U.S. Civilian And Development Foundation (ECSP-09-36_SASP) (Pt) 2009-2010
Title: Synthesis of asymmetrically meso-substituted cationic (metallo)porphyrins and investigation of their biological activity at cellular level
Armenian National Science and Education Fund (NS-BIOTECH-1387) (Pt) 2008-2009
Title: Synthesis of New Water-Soluble (Metallo)Porphyrins and Investigation of Their Anticancer Activities in vitro and in vivo
National Foundation of Science and Advanced Technologies (GRASP 29/06) (Pt) 2006-2007
Title: The cytotoxic action of new Ag-porphyrin as a potential chemotherapeutic agent
List of publications
- Gohar Tsakanova, Nelly Babayan, Elena Karalova, Lina Hakobyan, Liana Abroyan, Aida Avetisyan, Hranush Avagyan, Sona Hakobyan, Arpine Navasardyan, Bagrat Baghdasaryan, Elina Arakelova, Violetta Ayvazyan, Lusine Matevosyan, Arpine Navasardyan, Hakob Davtyan, Lilit Apresyan, Arsham Yeremyan, Rouben Aroutiounian, Andreyan N. Osipov, Bagrat Grigoryan, Zaven Karalyan. Low Energy Laser Driven Ultrashort Pulsed Electron Beam Irradiation Induced Immune Response in Rats. Int J Mol Sci, 2021, 22(21), 11525; https://doi.org/10.3390/ijms222111525
- Gohar Tsakanova, Elina Arakelova, Lusine Matevosyan, Mariam Petrosyan, Seda Gasparyan, Kristine Harutyunyan, and Nelly Babayan. The role of women scientists in the development of ultrashort pulsed laser technology-based biomedical research in Armenia. International Journal of Radiation Biology, 2021, https://doi.org/10.1080/09553002.2021.1987566
- Н.С.Бабаян, Д.В.Гурьев, Н.Ю.Воробьева, Б.А.Григорян, Г.Л.Тадевосян, Л.С.Апресян, А.К.Чигасова, Е.И.Яшкина, С.М.Роднева, А.А.Цишнатти, Ю.А.Федотов, Н.К.Саркисян, А.Т.Манукян, Р.М.Арутюнян, А.Н.Осипов. Колониеобразующая способность и остаточные фокусы белков репарации ДНК в фибробластах лёгких человека, облучённых субпикосекундными пучками ускоренных электронов. Бюллетень экспериментальной биологии и медицины, 2021, T. 172, № 7, 30-33. doi: 10.47056/0365-9615-2021-172-7-30-33
- Gohar Tsakanova, Violetta Ayvazyan, Elina Arakelova, Anna Ayvazyan, Stepan Tatikyan, Laura Djavadovna, Nelly Babayan, Ruzanna Grigoryan, Natalya Sargsyan, Arsen Arakelyan. Helix Pomatia albumen gland water soluble protein extract as powerful antiaging agent. Experimental Gerontology. 2021 Jan 15;146:111244. doi: 10.1016/j.exger.2021.111244
- Babayan, N.; Vorobyeva, N.; Grigoryan, B.; Grekhova, A.; Pustovalova, M.; Rodneva, S.; Fedotov, Y.; Tsakanova, G.; Aroutiounian, R.; Osipov, A. Low Repair Capacity of DNA Double-Strand Breaks Induced by Laser-Driven Ultrashort Electron Beams in Cancer Cells. Int. J. Mol. Sci. 2020, 21, 9488. https://doi.org/10.3390/ijms21249488
- Nelly Babayan, Bagrat Grigoryan, Lusine Khondkaryan, Gohar Tadevosyan, Natalya Sarkisyan, Ruzanna Grigoryan, Lilit Apresyan, Rouben Aroutiounian, Natalia Vorobyev, Margarita Pustovalova, Anna Grekhova and Andreyan N. Osipov. Laser Driven Ultrashort Pulsed Electron Beam Radiation at Doses of 0.5 and 1.0 Gy Induces Apoptosis in Human Fibroblasts. Int. J. Mol. Sci. 2019, 20, 5140; doi:10.3390/ijms20205140
- Nersesova L.S., Petrosyan M.S., Babayan N.S., Tadevosyan G.L., Khondkaryan L.G., Akopian J.I. Radioprotective effect of creatine on DNA damage in peripheral blood mononuclear cells and adaptive properties of brain and liver creatine-creatine. «Radiation and Risk», 2019, vol. 28, No. 3, pp.119-131 DOI: 10.21870/0131-3878-2019-28-3-119-131
- Babayan N, Tadevosyan G, Khondkaryan L, Grigoryan R, Sarkisyan N, Haroutiounian R, Stopper H. Ochratoxin A induces global DNA hypomethylation and oxidative stress in neuronal cells in vitro. Mycotoxin Res. 2019, 36(1), 73-81. doi: 10.1007/s12550-019-00370-y.
- Harutyunyan Karina, Balayan Karine, Tadevosyan Gohar, Hayrapetyan Manush, Musayelyan Ruzanna, Grigoryan Ruzanna, Sarkisyan Natalya, Khondkaryan Lusine, Babayan Nelly. Genotoxic potential of selected medicinal plant extracts in human whole blood cultures. J Herbmed Pharmacol, 2019; 8(2):160-162. doi: 10.15171/jhp.2019.25.
- Babayan N, Grigoryan B, Hovhannisyan G, Tadevosyan G, Khondkaryan L, Grigoryan R, Sarkisyan N, Aroutiounian R. Gender differences in DNA damage/repair after laser-generated ultrafast electron beam irradiation. Int J Radiol Radiat Ther. 2018;5(2):85–86.
- Babayana N., Hovhannisyan G., Grigoryan B., Grigoryan R., Sarkisyan N., Tsakanova G., Haroutiunian S., Aroutiounian R. Dose-rate effect of ultrashort electron beam radiation on DNA damage and repair in vitro. Journal of Radiation Research. 2017, 58(6): 1–4. doi: 10.1093/jrr/rrx046
- Thooptianrat T., Chaveerach A., Sudmoon R., Tanee T., Liehr T., Babayan N. Screening of phytochemicals and toxicity of medicinal plants, Dillenia species, reveals potential natural product resources. J Food Biochem. 2017; 41(3): e12363. https://doi.org/10.1111/jfbc.12363
- Hovhannisyan G., Aroutiounian R., Babayan N., Harutyunyan T., Liehr T. Comparative analysis of individual chromosome involvement in micronuclei induced by mitomycin C and bleomycin in human leukocytes. Molecular Cytogenetics, 2016; 9:49. doi: 10.1186/s13039-016-0258-4
- V.M. Tsakanov, R.M. Aroutiounian, G.A. Amatuni, L.R. Aloyan, L.G. Aslanyan, V.Sh. Avagyan, N.S. Babayan et al. AREAL low energy electron beam applications in life and materials sciences. Nucl Instrum Methods Phys Res A. 2016; 829: 248–253. https://doi.org/10.1016/j.nima.2016.02.028
- Malakyan M, Babayan N, Grigoryan R et al. Synthesis, characterization and toxicity studies of pyridinecarboxaldehydes and L-tryptophan derived Schiff bases and corresponding copper (II) complexes. F1000Research 2016, 5:1921. doi: 10.12688/f1000research.9226.1
- T. Harutyunyan, G. Hovhannisyan, N. Babayan, M.A.K. Othman, T. Liehr, R. Aroutiounian. Influence of aflatoxin B1 on copy number variants in human leukocytes in vitro. Molecular Cytogenetics, 2015, 8:25.
- A.Tovmasyan, N.Babayan, D.Pogosyan, K.Margaryan, R.Grigoryan, N.Sarkisyan, S.Mamyan, L.Sahakyan, R.Aroutiounian, R.Ghazaryan, G.Gasparyan. Novel amphiphilic cationic porphyrin and its Ag(II) complex as potential anticancer agents. Journal of Inorganic Biochemistry, 140, 2014, 94–103.
- E.R. Arakelova, Z.M. Farmazyan, A.M. Khachatryan, K.E. Avjyan, N.S. Babayan, R.M. Grigoryan, N.K. Sarkisyan, Sh.R.Singh. In vitro study of anticancer activity of polymer-based DOX-ZnO compositions: the case of vinyl alcohol (co)polymers. Journal of Nanogenomics and Nanomedicine, North America, 2, apr. 2014, 1-11.
- E.R. Arakelova, S.G. Grigoryan, F.G. Arsenyan, N.S. Babayan, R.M. Grigoryan, N.K. Sarkisyan. In vitro and in vivo Anticancer Activity of Nanosize Zinc Oxide Composites of Doxorubicin. International Journal of Medical, Pharmaceutical Science and Engineering, Vol:8 No:1, 2014, 33-38.
- Tovmasyan A, Babayan N, Sahakyan L, Shahkhatuni A, Gasparyan G, Aroutiounian R, Ghazaryan R. Synthesis and in vitro anticancer activity of water-soluble cationic pyridylporphyrins and their metallocomplexes. J. Porphyrins Phthalocyanines, 2008 (12), 1100-1110.
- Tovmasyan A, Babayan N, Ghazaryan R, Sahakyan L, Gasparyan G, Gyulkhandanyan G. New water-soluble cationic metalloporphyrins as potential anticancer agents. J. Biomol. Struct. Dynamics, 2007 (26), 682-683.