Department of Medical Biochemistry and Biotechnology

Information

Scientific interests

• Biochemistry
• Biophysics
• Bioinformatics
• Bioengineering
• Biotechnology
• Molecular biology
• Nanobiotechnology

List of publications

• Vardapetyan HR, Kirakosyan AB, Hovhannisyan A. et al, Effect of various elicitors on lignan biosynthesis in callus cultures of Linum austriacum // Rus. J. of “Plant Physiology”, v.50, N3, p.297 –301, 2003.
• Vardapetyan H.R., Tiratsuyan S.G., Hovhannisyan A.A. Martirosyan A.S., Possibility of improvement of hemoglobin properties as biosensors’ detection element. In Biophotonics: Photonic Solutions for Better Health Care II, edited by Jürgen Popp, Wolfgang Drexler, Valery V. Tuchin, Dennis L. Matthews, Proc. of SPIE Vol. 7715 (SPIE, Bellingham, WA, 2010) 77153N, p.77153N-1 – 77153N-8. doi:10.1117/12.852765.
• Vardapetyan HR, Tiratsuyan SG, Hovhannisyan AA. Martirosyan AS, Biphasic dose–response of antioxidants in hypericin-induced photohemolysis // Photodiagnosis and Photodynamic Therapy, 2011, 8(3), 282-7. doi:10.1016/j.pdpdt.2011.03.339.
• Vardapetyan H.R., Martirosyan A.S., Tiratsuyan S.G., Hovhannisyan A.A. Interaction between hypericin and hemoglobin. J. Photochem. Photobiol. B: Biol. 101 (2010) p. 53-58, PMID: DOI: 10.1016 / j.jphotobiol.2010.06.011.
• Vardapetyan H.R., Tiratsuyan S.G., Hovhannisyan A.A., Martirosyan A.S., Improvement of hypericin properties as an anticancer agent // Annals of Oncology, Abstract book IMPAKT 2010 Breast Cancer Conference, Brussels, Belgium, 6-8 May V. 21, Suppl. 4, v.58, 134P, 2010.
• Vardapetyan H.R., Tiratsuyan S.G., Hovhannisyan A.A. Martirosyan A.S., “Improvement of hemoglobin peroxidase activity via hypericin”, FEBS J., 36th FEBS Congress “Biochemistry for Tomorrow’s Medicine”, Torino, Italy, 25-30 June, 2011, V. 278, Suppl. 1, P08.23, p.159-160.
• Vardapetyan H.R., Tiratsuyan S.G., Hovhannisyan A.A., Martirosyan A.S., “Elucidation of DPPH radical scavenging, antibacterial and photodynamic activities of Hypericum perforatum extracts’, BJA, 2012, v.64, N 2, p. 111-116.
• Vardapetyan H., Tiratsuyan S., Hovhannisyan A., Rukhkyan M., Hovhannisyan D. “Phytochemical composition and biological activityof Laurus nobilis L. leaves collected from two regions of South Caucasus’ // Journal of Experimental Biology and Agricultural Sciences, vol 1, issue 2, pp. 45-51, 2013.
• H. Vardapetyan, AA Hovhannisyan, S Tiratsuyan, Study of photodynamic activity of hypericin and synthetic photosensitizers on haemolysis of erythrocytes in vitro // Proceedings of SPIE - The International Society for Optical Engineering V. 6087, 2006, Article number 608706 Biophotonics and Immune Responses; San Jose, CA; United States; 23, 24 January 2006 through; Code 67211. proceedings.spiedigitallibrary.org
• HR Vardapetyan, AA Hovhannisyan, SG Tiratsuyan, et al. Substrate specificity of Peroxidases // Vestnik IAELPS regional issue, V.10, № 5, p. 161-164, 2005.
• Vardapetyan H., Tiratsuyan A., Hovhannisyan A. Hepatoprotective activity of leaf extract of Laurus nobilis L. against CCl4 induced hepatotoxicity in rats // IFMBE CONFERENCE 3rd International Conf. on Nano¬technologies and Biomedical Engineering (ICNBME-2015) vol. 55, p.419-423, 2015. DOI:10.1007/978-981-287-736-9_99.
• S.G. Tiratsuyan A.A. Hovhannisyan, A.V. Karapetyan, T.A. Gomktsyan, A.P. Yengoyan, Synthesis and biological activities of novel pyridazine derivatives // Russian Journal of Plant Physiology, V. 63, Issue 5, pp 656–662, 2016. https://doi.org/10.1134/S1021443716050125.
• Оганесян A.A., Вардапетян Г.Р. «Зеленая биотехнология», Культуры раcтитeльных клeток и тканeйв биологии и медицине // Издательство «Асогик» 2017. Проект BME-ENA “Темпус инициатива в сфере Биомедицинского инженерного образования в регионе Восточного Соседства”. ISBN 978-9939-50-352-3, 2017.
• Оганесян А.А., Рштуни Л.Р., Вардапетян Г.Р., Геворкян В.А. Действие наноразмерного серебра на морфофизиологические свойства каллусных культур Linum ausriacum L. // «Физико-химическая биология» материалы IV международной научной интернет-конференции, Материалы III междунар. науч.-практ. конф. – Ставрополь : Изд-во СтГМУ, 24-27, 2017.
• Ohanyan A., Shishkoyan N., Kazaryan Sh., Hovhannisyan A., Tiratsuyan S., Elbekyan K., Koshel V., Khodzhayan A. Antioxidant and Hemolytic Properties of Different Extracts from Prunella vulgaris L. Leaves. Medical News of North Caucasus 2018. 13(3), 507-510. DOI – https://doi.org/10.14300/mnnc.2018.13091.
• Чилингарян Г.В., Оганесян A. А., Гиносян С.В., Тирацуян С.Г. Теломерные Г- Квадруплексные Мотивы ДНК как Потенциальная Мишень Новых Антималярийных Препаратов. VI Международная научная интернет конференция Физико-химическая биология Ставрополь 2018, ноябрь 27-29, 9-12.
• Оганесян А.А., Вардапетян Г.Р., Арутюнян А.А., Тирацуян С.Г., Казарян Ш.А., Петросян М.С. Исследование действия миллиметровых волн на антиоксидантную систему суспензионных культур Linum ausriacum L. VIII Международный конгресс "Слабые и сверхслабые поля и излучения и в биологии и медицине" 10-15.09.2018, Санкт-Петербург, стр. 67-68.
• Kazaryan Sh., M. Petrosyan, L. Rshtuni, V. Dabaghyan, and A. Hovhannisyan Effects of Green Silver Nanoparticles on CCl4 Injured Albino Rats’ Liver. 4th International Conference on Nanotechnologies and Biomedical Engineering Proceedings of ICNBME-2019, September 18–21, 2019, Chisinau, Moldova. V 77, 127-133. https://doi.org/10.1007/978-3-030-31866-6_27
• Ohanyan S., Grabski H., Rshtuni L., Tiratsuyan S., Hovhannisyan A. Improvement of the Antibacterial Activity of Benzylpenicillin in Combination with Green Silver Nanoparticles Against Staphylococcus aureus. 4th International Conference on Nanotechnologies and Biomedical Engineering Proceedings of ICNBME-2019, September 18–21, 2019, Chisinau, Moldova. V.77, 349-355. https://doi.org/10.1007/978-3-030-31866-6_6
• Petrosyan M., Gevorgyan T., Kirakosyan G., Ghulikyan L., Hovhannisyan A., Ayvazyan N. Testing Green Silver Nanoparticles for Genotoxicity, Antioxidant and Anticancer Activity 4th International Conference on Nanotechnologies and Biomedical Engineering Proceedings of ICNBME-2019, September 18–21, 2019, Chisinau, Moldova. 567-579. https://doi.org/10.1007/978-3-030-31866-6_101
• Khachatryan A., Khasaryan Sh., Tiratsuyan S., Hovhannisyan A."ANTIBACTERIAL EFFECT OF SILVER AND IRON OXIDE Fe3O4 NANOPARTICLES IN COMBINATION WITH ANTIBIOTICS ON E. coli" 2019, BioNanoScience, Springer New York, LCC, vol. 9, p. 587–596, DOI: 10.1007/s12668-019-00640-0.
• Казарян Ш.А., Рштуни Л.Р., Оганесян А.А. Синергизм антибактериального действия наночастиц серебра и экстракта T. polium. Сборник Научных Трудов VI Съезда Биофизиков России: в 2 томах, 2019, 253, DOI: 10.31429/SbR6.2019.001 http://conf-2019.biophys.ru/work/BioPhys-2019_V1.pdf
• Казарян Ш.А., Рштуни Л.Р., Петросян М.С., Каралян Н.Ю., Оганесян А.А. Влияние зеленых наночастиц серебра на биохимические показатели функционирования печени крыс Сборник Научных Трудов VI Съезда Биофизиков России: в 2 томах, 2019, 254, DOI: 10.31429/SbR6.2019.001 http://conf-2019.biophys.ru/work/BioPhys-2019_V1.pdf
• Farsiyan L., Hovhannisyan A., Arutyunyan A., “Iron Oxide Nanoparticles Green Synthesis”, Current advances in pathogen research, FEBS, March 25-30, 2019, Yerevan, Armenia. pp. 45-46.
• Gabrielyan L, A Hovhannisyan, V Gevorgyan, M Ananyan, A Trchounian “Antibacterial effects of iron oxide (Fe3O4) nanoparticles: distinguishing concentration-dependent effects with different bacterial cells growth and membrane”. Applied Microbiology and Biotechnology. Publisher NameSpringer Berlin Heidelberg March 2019, Volume 103, Issue 6, pp 2773–2782 https://doi.org/10.1007/s00253-019-09653-x
• Gabrielyan L, Hakobyan L, Hovhannisyan A, Trchounian A “Effects of iron oxide (Fe3O4) nanoparticles on Escherichia coli antibiotic resistant strains” Journal of applied microbiology, Volime 126, Issue 4, pp 1108-1116 https://doi.org/10.1111/jam.14214
• Arutyunyan A., Hovhannisyan A., Kazarian Sh., Tiratsuyan S. “Effect of silver nanoparticles on peroxidase activity of Linum ausriacum L. and Hypericum perforatum L. callus culture”, March 2019, Toxicon, 159:S21 DOI: 10.1016/j.toxicon.2018.11.387.
• Hovhannisyan A., Arutyunyan А., Ohanyan А., Chilingaryan G. “Investigation of the action of silver nanoparticles on the biosynthesis of podophyllotoxins of L. austriacum suspension cultures”, March 2019, Toxicon, 159: S24-S25 DOI: 10.1016/j.toxicon.2018.11.401.
• Manukyan A.E., Hovhannisyan A.A.- Evaluation of the quercetin semisynthetic derivatives interaction with Breast Cancer Resistance Protein. Biorxiv 2020, https://doi.org/10.1101/2020.09.12.292821 (doi: 10.1101/2020.09.12.292821)
• Manukyan A.E., Hovhannisyan A.A. The quercetin and quercetin derivatives interaction with cyclooxygenase-1 and cyclooxygenase-2. bioRxiv 2020.12.05.413088; doi: https://doi.org/10.1101/2020.12.05.413088
• Ohanyan S.A., Rshtuni L.R., Grabski H.V., Tiratsuyan S.G., Hovhannisyan A.A. Antibacterial Action of Chemical and Green Silver Nanoparticles In Combination With Antibiotics // Biolog. Journal of Armenia, 2019. V.71 (3), P.89-96. http://biology.asj-oa.am/11615/1/89.pdf
• Khachatryan A., Khasaryan Sh., Tiratsuyan S., Hovhannisyan A."Antibacterial effect of silver and iron oxide Fe3O4 nanoparticles in combination with antibiotics on E. coli" 2019, BioNanoScience, Springer New York, LCC, 9(11), 587-596. DOI: 10.1007/s12668-019-00640-0
• Казарян Ш.А., Рштуни Л.Р., Оганесян А.А. Синергизм антибактериального действия наночастиц серебра и экстрактов T. Polium. БИОФИЗИКА, 2021, 66(4), 734–740. DOI: 10.31857/S000630292104013X
• Kazaryan, S.A., Rshtuni, L.R. & Hovhannisyan, A.A. The Synergistic Antibacterial Activity of Silver Nanoparticles and T. polium Extracts. BIOPHYSICS, 2021, 66, 623–628 https://doi.org/10.1134/S0006350921040084
• Farsiyan L.M., Kazaryan Sh.A., Hovhannisyan A.A. Comparative Analysis of Iron Oxide Nanoparticle’s (Fe3O4) Cytotoxicity Synthesized by Chemical and Biogenic Methods. IFMBE Proceedings. 2022, 87, 48–54. Springer, Cham. https://doi.org/10.1007/978-3-030-92328-0_7
• Kazaryan Sh., Farsiyan L., Tumoyan J., Kirakosyan G., et al. Oxidative stress and histopathological changes in several organs of mice injected with biogenic silver nanoparticles. Artificial Cells, Nanomedicine, and Biotechnology, 2022, 50(1), 331-342, https://doi.org/10.1080/21691401.2022.2149931
• Ohanyan, S., Rshtuni, L., Hovhannisyan, A. (2024). Antibacterial Activity of “Green” Silver Nanoparticles (AgNPs) in Combination with Benzylpenicillin and Kanamycin. In: Sontea, V., Tiginyanu, I., Railean, S. (eds) 6th International Conference on Nanotechnologies and Biomedical Engineering. ICNBME 2023. IFMBE Proceedings, vol 91. Springer, Cham. https://doi.org/10.1007/978-3-031-42775-6_57
• Tiratsuyan, S., Hambardzumyan, Y., Poghosyan, M., Danielyan, M., Hovhannisyan, A. (2024). In vivo and in silico Studies of the Neuroprotective Effect of Artemisinin in Prevention of Alzheimer’s Disease in an Animal Model. In: Sontea, V., Tiginyanu, I., Railean, S. (eds) 6th International Conference on Nanotechnologies and Biomedical Engineering. ICNBME 2023. IFMBE Proceedings, vol 92. Springer, Cham. https://doi.org/10.1007/978-3-031-42782-4_22
• Tumoyan, J., Kazaryan, S., Hovhannisyan, A. (2024). The Impact of Biogenic Silver Nanoparticles on the Enzymatic Antioxidant System of Wistar Rats’ Kidney. In: Sontea, V., Tiginyanu, I., Railean, S. (eds) 6th International Conference on Nanotechnologies and Biomedical Engineering. ICNBME 2023. IFMBE Proceedings, vol 91. Springer, Cham. https://doi.org/10.1007/978-3-031-42775-6_58

File information

• Biotechnology
• Medical Biotechnology
• Cell"s signal systems
• Molecular mechanisms of cancerogenesis
• Biotechnology of microorganisms

Managers

• Arsenyan Arpine