About
Education:
1996 Ph.D; Field: Molecular Biology and Genetics
1990-1993 Ph.D. student, Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia
1979-1984 Yerevan State University, Faculty of Biology, Biophysics
Employments:
2017- at present Lecturer, Russian-Armenian University
2017- at present Head of Laboratory of Microbial Genomics, Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia
2003- 2017 Senior researcher at the Laboratory of Molecular Genetics, Institute of Molecular Biology of NAS, RA
1998-2003 Researcher, Laboratory of Molecular Genetics, Institute of Molecular Biology of NAS, RA
1991-1996 Laboratory assistant, Institute of Molecular Biology of NAS, RA
Grants:
2018-2020 Ministry of Education, Science, Culture and Sport RA, Science Committee (18T-1F405 Project) “Development of approaches for bacteriophage based prophylaxis and treatment of the prevalent in Armenia foodborne infectious diseases of bacterial origin” PI of the project
2016-2018 ISTC Project #A-2140 Targeted elimination of multidrug-resistant (MDR) Salmonella by bacteriophages; Manager
2014-2015 Armenian National Science and Education Fund (ANSEF, USA) “molbio-3581” Molecular characterization of genetic basis of multi-drug resistance in non-typhoidal Salmonella enterica strains isolated from patients in Armenia; PI of the project
Current research activities:
Study of highly virulent and multidrug resistant strains of bacterial pathogens circulating in Armenia. Development of phage therapy approaches to control spread of infectious diseases and antimicrobial resistance in Armenia.
Scientific interests
- Microbial genomics
- Molecular genetics of microorganisms
- Mechanisms of antibiotic resistance
- Infectious diseases
- Microbial ecology in health and disease.
List of publications
- 1. Zakharyan M. K., Arakelova K. A., Gevorgyan Z. U., Sedrakyan A. M. Efflux Pumps in Non-Typhoidal Salmonella Isolates Recovered from Patients in Armenia. Reports of NAS RA, 2021, V. 121, N4.
- 2. Sedrakyan AM, Ktsoyan ZA, Arakelova KA, Zakharyan MK, Hovhannisyan AI, Gevorgyan ZU, Mnatsakanyan AA, Kakabadze EG, Makalatia KB, Chanishvili NA, Pirnay J-P, Arakelyan AA and Aminov RI (2020) Extended-Spectrum β-Lactamases in Human Isolates of Multidrug-Resistant Non-typhoidal Salmonella enterica. Frontiers in Microbiology. 11:592223. doi: 10.3389/fmicb.2020.59222.
- 3. Makalatia, K.; Kakabadze, E.; Wagemans, J.; Grdzelishvili, N.; Bakuradze, N.; Natroshvili, G.; Macharashvili, N.; Sedrakyan, A.; Arakelova, K.; Ktsoyan, Z.; Zakharyan, M.; Gevorgyan, Z.; Mnatsakanyan, A.; Tishkova, F.; Lood, C.; Vandenheuvel, D.; Lavigne, R.; Pirnay, J.-P.; De Vos, D.; Chanishvili, N.; Merabishvili, M. Characterization of Salmonella Isolates from Various Geographical Regions of the Caucasus and Their Susceptibility to Bacteriophages. Viruses 020, 12, 1418. https://doi.org/10.3390/v12121418.
- 4. Ktsoyan, Z.; Budaghyan, L.; Agababova, M.; Mnatsakanyan, A.; Arakelova, K.; Gevorgyan, Z.; Sedrakyan, A.; Hovhannisyan, A.; Mkrtchyan, M.; Zakharyan, M.; Arakelyan, A.; Aminov, R. Potential Involvement of Salmonella Infection in Autoimmunity, Pathogen 2019, 8, 96. https://doi.org/10.3390/pathogens8030096.
- 5. Kakabadze, E.; Makalatia, K.; Grdzelishvili, N.; Bakuradze, N.; Goderdzishvili, M.; Kusradze, I.; Phoba, M.-F.; Lunguya, O.; Lood, C.; Lavigne, R.; Jacobs, J.; Deborggraeve, S.; De Block, T.; Van Puyvelde, S.; Lee, D.; Coffey, A.; Sedrakyan, A.; Soentjens, P.; De Vos, D.; Pirnay, J.-P.; Chanishvili, N. Selection of Potential Therapeutic Bacteriophages that Lyse a CTX-M-15 Extended Spectrum β-Lactamase Producing Salmonella enterica Serovar Typhi Strain from the Democratic Republic of the Congo. Viruses 2018, 10, 172. https://doi.org/10.3390/v10040172.
- 6. Zhanna A. Ktsoyan, Mkhitar S. Mkrtchyan, Magdalina K. Zakharyan, Armine A. Mnatsakanyan, Karine A. Arakelova, Zaruhi U. Gevorgyan, Anahit M. Sedrakyan, Alvard I. Hovhannisyan, Arsen A. Arakelyan and Rustam I. Aminov. Systemic Concentrations of Short Chain Fatty Acids Are Elevated in Salmonellosis and Exacerbation of Familial Mediterranean Fever. May 2016, Frontiers in Microbiology 7(101) DOI:10.3389/fmicb.2016.00776.
- 7. Ktsoyan Z, Mkrtchyan M, Zakharyan M, Mnatsakanyan A, Arakelova K, Gevorgyan Z, Ktsoyan L, Sedrakyan A, Hovhannisyan A, Ghazaryan K, Boyajyan A and Aminov R (2015) Differential induction of total IgE by two Salmonella enterica serotypes. Frontiers in Cellular and Infection Microbiology 5:43. doi:10.3389/fcimb.2015.00043.
- 8. Ktsoyan ZhA., Beloborodova NV, Sedrakyan AM, Osipov GA, Khachatryan ZA, Manukyan GP,Arakelova KA, Hovhannisyan AI, Arakelyan AA, Ghazaryan KA, Zakaryan MK and Aminov RI. Management of familial Mediterranean fever by colchicine does not normalize the altered profile of microbial long chain fatty acids in the human metabolome. Frontiers in Cellular and Infection Microbiology, 2013 January, V.3, Article 2, 1-8. doi:10.3389/fcimb.2013.00002.
- 9. Седракян А.М., Аракелова К.А., Закарян М.К., Оганнисян А.И., Асоян А.В., Геворкян З.У., Мнацаканян А.A., Кцоян Ж.А., Бояджян А.С., Аминов Р.И. Множественная лекарственная устойчивость и интегроны 1-го класса клинических изолятов Salmonella enterica серотипа Enteritidis, циркулирующих в Армении. Инфекция и иммунитет, 2013, т.3, № 4. С.355-358.
- 10. Седракян А.М., Аракелова К.А., Геворкян З.У., Мнацаканян А.А., Закарян М.К., Оганисян А.И., Асоян А.В., Кцоян Ж.А. Множественная лекарственная устойчивость клинически значимых серотипов возбудителей сальмонеллёзов. Биологический журнал Армении, 2013, №. 4 (65), С. 13-19.
- 11. Zh.A. Ktsoyan, K.A. Ghazaryan, G.P. Manukyan, A. Martirosyan, А.А. Mnatsakanyan, К.А. Arakelova, Z.U. Gevorgyan, A.M. Sedrakyan, A.V. Asoyan, А.S. Boyajyan and R.I. Aminov Inflammatory responses to Salmonella infections are serotype-specific. Hindawi Publishing Corporation International Journal of Bacteriology Volume 2013, Article ID 168179, 7 pages http://dx.doi.org/10.1155/2013/168179.
- 12. Ktsoyan Zh.A., Ghazaryan K.A., Martirosyan A.A., Mnatsakanyan A.A., Arakelova K.A., Gevorgyan Z.U., Tatyan M.V., Hovhannisyan A.I., Sedrakyan A.M., Zakaryan M.K., Arakelyan A.A., Boyajyan A.S., Aminov R.I. Profile of proinflammatory response in salmonellosis depends on serotype of the pathogen. Cytokines and Inflammation, 2013, 12 (1-2), 131-136.
- 13. M.K. Zakharyan, A.M. Sedrakyan, K.A. Arakelova, A.I. Hovannisyan, A.V. Asoyan, Z.U. Gevorgyan, A.A. Mnatsakanyan, Zh.A. Ktsoyan, A.S. Boyajyan and R.I. Aminov Antibiotic resistance and occurrence of class 1 integrons in clinical isolates of Salmonella enterica. Global Journal of Immunology and Allergic Diseases, 2013, 1, 44-48.
- 14. Zhanna A Ktsoyan, Natalia V Beloborodova, Anahit M Sedrakyan, George A Osipov, Zaruhi A Khachatryan, Denise Kelly, Gayane P Manukyan, Karine A Arakelova, Alvard I Hovhannisyan, Andrey Y Olenin, Arsen A Arakelyan, Karine Ghazaryan, Rustam I Aminov. Profiles of microbial fatty acids in the human metabolome are disease-specific. Frontiers in Cellular and Infection Microbiology. 2010, 1:148; doi:10.3389/fmicb.2010.00148 January 2011, V.1, 148, P.1-9.
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