Оганесян Галина Георгиевна

д.б.н., профессор


Доктор биологических наук, профессор кафедры биоинженерии, биоинформатики и молекулярной биологии Института Биомедицины и Фармации Российско-Армянского Университета

Образование: высшее, биологический факультет ЕГУ (1978-1983)
Опыт работы: Преподаватель кафедры генетики и цитологии биологического факультета ЕГУ с 2000 года, в настоящее время профессор кафедры генетики и цитологии биологического факультета ЕГУ. Старший научный сотрудник лаборатории общей и молекулярной генетики Института биологии ЕГУ
Специализация: Генетика
Читаемые дисциплины: Цитогенетика
Повышение квалификации: 5-летний курс ФПК ЕГУ, 2016 год

Награды, гранты:
Тематический грант Комитета по науке Министерство образования, науки, культуры и спорта РА (18T‐1F039, 2018)
Establishment of the Armenian-German Joint Research Laboratory for developmen of research and educational programs in the field of molecular cytogenetics in Armenia (ՀԳ-01/20, SCS-BMBF, Armenia-Germany, 2020)
Золотая медаль ЕГУ


Научные интересы

  • Молекулярная цитогенетика
  • Генетическая токсикология
  • Экологическая генетика

Список основных публикаций

  • 1. Arutyunyan RM, Hovhannisyan GG, Ghazanchyan EG, Oganessian NM, Nersesyan AK. UV-C induced DNA damage in leukocytes of Chernobyl accident clean-up workers. Experimental Oncology, 2000, 22: 219-221.
  • 2. Arutyunyan R, Gebhart E, Hovhannisyan G, Greulich KO, Rapp A. Comet-FISH using peptide nucleic acid probes detects telomeric repeats in DNA damaged by bleomycin and mitomycin C proportional to general DNA damage. Mutagenesis. 2004 Sep;19(5):403-8. doi: 10.1093/mutage/geh049. PMID: 15388814.
  • 3. Hovhannisyan GG, Haroutunyan TS, Arutyunyan RM. Detection of cisplatin-DNA crosslinks formation with UV-C application by the alkaline comet-assay. Exp Oncol. 2004, 26(3): 240-242.
  • 4. Hovhannisyan G, Rapp A, Arutyunyan R, Greulich KO, Gebhart E. Comet-assay in combination with PNA-FISH detects mutagen-induced DNA damage and specific repeat sequences in the damaged DNA of transformed cells. Int J Mol Med. 2005 Mar;15(3):437-42. doi: 10.3892/ijmm.15.3.437. PMID: 15702234.
  • 5. Arutyunyan RM, Rapp A, Greulich KO, Hovhannisyan G, Haroutiunian S, Gebhart E. Fragility of telomeres after bleomycin and cisplatin combined treatment measured in human leukocytes with the Comet-FISH technique. Exp Oncol. 2005, 27(1):38-42.
  • 6. Hovhannisyan G, Haroutiunian S, Margaryan K, Ghazaryan R, Aroutiounian R. DNA damage induced by new pophyrins of different chemical structure. Korean J. Environ. Biol. 2005, 23(4): 379-382.
  • 7. Aroutiounian R, Hovhannisyan G, Gasparyan G. Genetic effects of electromagnetic waves. Brilliant Light in Life and Material Sciences, Springer 2007, 251-265.
  • 8. Gasparyan G, Hovhannisyan G, Ghazaryan R, Sahakyan L, Tovmasyan A, Grigoryan R, Sarkissyan N, Haroutiunian S, Aroutiounian R. In vitro testing of cyto- and genotoxicity of new porphyrin water-soluble metal derivatives. Int J Toxicol. 2007 Nov-Dec;26(6):497-502. doi: 10.1080/10915810701707056. PMID: 18066965.
  • 9. Hovhannisyan G, Mkrtchyan H, Liehr T, Aroutiounian R. Involvement of chromosomes 7, 18 and X in mitomycin C-induced micronuclei. Balkan Journal of Medical Genetics (BJMG) 2008, 11(2):45-49.
  • 10. Glei M, Hovhannisyan G, Pool-Zobel BL. Use of Comet-FISH in the study of DNA damage and repair: review. Mutat Res. 2009 Jan-Feb;681(1):33-43. doi: 10.1016/j.mrrev.2008.01.006. Epub 2008 Jan 31. PMID: 18304859.
  • 11. Hovhannisyan G, Aroutiounian R, Glei M. Butyrate reduces the frequency of micronuclei in human colon carcinoma cells in vitro. Toxicol In Vitro. 2009 Sep;23(6):1028-33. doi: 10.1016/j.tiv.2009.06.011. Epub 2009 Jun 17. PMID: 19539745.
  • 12. Hovhannisyan GG. Fluorescence in situ hybridization in combination with the comet assay and micronucleus test in genetic toxicology. Mol Cytogenet. 2010 Sep 15;3:17. doi: 10.1186/1755-8166-3-17. PMID: 20840797; PMCID: PMC2949878.
  • 13. Hovhannisyan G, Aroutiounian R, Liehr T. Chromosomal composition of micronuclei in human leukocytes exposed to mitomycin C. J Histochem Cytochem. 2012 Apr;60(4):316-22. doi: 10.1369/0022155412436587. Epub 2012 Jan 18. PMID: 22260997; PMCID: PMC3351236.
  • 14. Harutyunyan T, Karapetyan A, Hovhannisyan G, Aroutiounian R. Combined Genotoxic Effects of Aflatoxin B1, Ochratoxin A and Zearalenone in Rat Bone Marrow and Blood Leukocytes. Korean J. Environ. Biol. 2013, 31(3): 189-191.
  • 15. Fan X, Sangpakdee W, Tanomtong A, Chaveerach A, Pinthong K, Pornnarong S, Supiwong W, Trifonov V, Hovhannisyan G, Loth K, Hensel Ch, Liehr T, Weise A. Comprehensive molecular cytogenetic analysis of Barbary Macaque (Macaca sylvanus). Biolog. Journal of Armenia, 2014, 1 (66): 98-102.
  • 16. Fan X, Sangpakdee W, Tanomtong A, Chaveerach A, Pinthong K, Pornnarong S, Supiwong W, Trifonov V, Hovhannisyan G, Aroutiounian RM, Liehr T, Weise A. Molecular cytogenetic analysis of Thai southern pig-tailed macaque (Macaca nemestrina) by multicolor banding. Proceedings of the Yerevan State University, 2014, 1: 46–50.
  • 17. Simonyan AE, Hovhannisyan GG, Aroutiounian RМ, Kim JK. Effect of N-acetyl-L-cysteine on human chronic myeloid leukemia cells KCL22 treated with mitomycin C. J. Ecol. Environ. 37(1): 31-34, 2014
  • 18. Harutyunyan T, Hovhannisyan G, Babayan N, Othman MA, Liehr T, Aroutiounian R. Influence of aflatoxin B1 on copy number variants in human leukocytes in vitro. Mol Cytogenet. 2015 Apr 9;8:25. doi: 10.1186/s13039-015-0131-x. PMID: 25901182; PMCID: PMC4404608.
  • 19. Manvelyan M, Simonyan I, Hovhannisyan G, Aroutiounian R, Hamid AB, Liehr T. A New Case of a Complex Small Supernumerary Marker Chromosome: A Der(9)t(7;9)(p22;q22) due to a Maternal Balanced Rearrangement. J Pediatr Genet 2015;4:199–200.
  • 20. Simonyan A, Gabrielyan B, Minasyan S, Hovhannisyan G, Aroutiounian R. Genotoxicity of Water Contaminants from the Basin of Lake Sevan, Armenia Evaluated by the Comet Assay in Gibel Carp (Carassius auratus gibelio) and Tradescantia Bioassays. Bull Environ Contam Toxicol. 2016 Mar;96(3):309-13. doi: 10.1007/s00128-015-1720-4. Epub 2016 Jan 7. PMID: 26739952.
  • 21. Hovhannisyan G, Aroutiounian R, Babayan N, Harutyunyan T, Liehr T. Comparative analysis of individual chromosome involvement in micronuclei induced by mitomycin C and bleomycin in human leukocytes. Mol Cytogenet. 2016 Jun 21;9:49.
  • 22. Harutyunyan T, Babayan N, Aroutiounian R, Hovhannisyan G. Cell viability and DNA damage in MRC5 and HeLa cell lines after histone H1 knockout by CRISPR-Cas9 genome editing technology. Proceedings of Yerevan State University, Chemistry and Biology 2016, 3:64–66.
  • 23. Babayan N, Hovhannisyan G, Grigoryan B, Grigoryan R, Sarkisyan N, Tsakanova G, Haroutiunian S, Aroutiounian R. Dose-rate effect of ultrashort electron beam radiation on DNA damage and repair in vitro. Journal of Radiation Research, 2017, pp. 1–4
  • 24. Hovhannisyan G, Harutyunyan T, Liehr T. PART V. INTERPHASE FISH. Micronucleus FISH, p. 379-385. Fluorescence in situ Hybridization (FISH) – Application Guide, T. Liehr (Editor), 2nd Ed., Springer, Berlin, 2017, ISBN: 978-3662529577.
  • 25. Hovhannisyan G, Aroutiounian R PART V. INTERPHASE FISH. Comet-FISH, p. 373-37. Fluorescence in situ Hybridization (FISH) – Application Guide, T. Liehr (Editor), 2nd Ed., Springer, Berlin, 2017, ISBN: 978-3662529577.
  • 26. Simonyan A, Hovhannisyan G, Sargsyan A, Arakelyan M, Minasyan S, Aroutiounian R. DNA damage and micronuclei in parthenogenetic and bisexual Darevskia rock lizards from the areas with different levels of soil pollution. Ecotoxicol Environ Saf. 2018 Jun 15;154:13-18. doi: 10.1016/j.ecoenv.2018.02.025. Epub 2018 Feb 22. PubMed PMID: 29453160.
  • 27. Hovhannisyan, G., Harutyunyan, T., Aroutiounian, R. Micronuclei and What They Can Tell Us in Cytogenetic Diagnostics. Curr Genet Med Rep (2018).
  • 28. Sargsyan A, Simonyan A, Hovhannisyan G, Arakelyan M, Aroutiounian R. Application of the comet assay, micronucleus test and global DNA methylation analysis in Darevskia lizards as a sentinel organism for genotoxic monitoring of soil pollution. Mutat Res. 2019 Jun;842:117-124. doi: 10.1016/j.mrgentox.2018.10.005. Epub 2018 Oct 25. PubMed PMID: 31255219.
  • 29. Hovhannisyan G, Harutyunyan T, Aroutiounian R, Liehr T. DNA Copy Number Variations as Markers of Mutagenic Impact. Int J Mol Sci. 2019 Sep 24;20(19):4723. doi: 10.3390/ijms20194723. PMID: 31554154; PMCID: PMC6801639.
  • 30. Harutyunyan T, Al-Rikabi A, Sargsyan A, Hovhannisyan G, Aroutiounian R, Liehr T. Doxorubicin-Induced Translocation of mtDNA into the Nuclear Genome of Human Lymphocytes Detected Using a Molecular-Cytogenetic Approach. Int J Mol Sci. 2020 Oct 17;21(20):7690. doi: 10.3390/ijms21207690. PMID: 33080837; PMCID: PMC7589397.