Описание

Научные интересы

• Биохимия
• Биофизика
• Молекулярная биология
• Биоинженерия
• Биоинформатика

Список основных публикаций

• Ginosyan, S., Grabski, H. & Tiratsuyan, S. In vitro and in silico Determination of the Interaction of Artemisinin with Human Serum Albumin. Mol Biol 54, 586–598. DOI: https://doi.org/10.1134/S0026893320040056, 2020
• С.В. Гиносян, О.В. Грабский, С.Г. Тирацуян. In vitro и in silico определение взаимодействия артемизинина с сывороточным альбумином человекa Молекулярная биология, 54(4), 653-666. DOI: 10.31857/S0026898420040059 , 2020
• Hambardzumyan Y., Ginosyan S., Tiratsuyan S. Comparative analysis of the interaction of inhibitors with BACE-1 using molecular modeling methods. “Biotechnology: Forward to the future”, Materials of VI International Scientific Internet-Conference, Stavropol, Russia, 12-15, ISBN 978−5−89822−581−0., 2020
• Abelyan, N., Grabski, H., & Tiratsuyan, S. In silico Screening of Flavones and its Derivatives as Potential Inhibitors of Quorum-Sensing Regulator LasR of Pseudomonas aeruginosa. Molecular Biology, 54(1), 134-143. DOI: https://doi.org/10.1134/S0026893320010021, 2020
• Абелян, Н., Грабский, О., & Тирацуян, С. In silico скрининг флавонов и их производных как потенциальных ингибиторов кворум-сенсинг регулятора LasR Pseudomonas aeruginosa. Молекулярная биология, 54(1), 153-163. DOI: 10.31857/S0026898420010024 , 2020
• Ginosyan, S.G., Chilingaryan, G.V., Grabski, H.V., Ghulikyan, L.A., Ayvazyan, N.M. and Tiratsuyan, S.G., 2019, September. Mode of Artemisinins’ Action on Oxidative Stress, Genomic and G-Quadruplex DNA. In International Conference on Nanotechnologies and Biomedical Engineering (pp. 543-548). Springer, Cham., 2020
• Grabski, H.V. and Tiratsuyan, S.G., 2019, September. Interaction of Quercetin with LasR of Pseudomonas aeruginosa: Mechanistic Insights of the Inhibition of Virulence Through Quorum Sensing. In International Conference on Nanotechnologies and Biomedical Engineering (pp. 585-588). Springer, Cham., 2020
• Ginosyan, S., Hambardzumyan, Y., Mkrtchyan, T., Grabski, H. and Tiratsuyan, S., 2019, September. Molecular Docking of Compounds Modulating Amyloid Peptide Aggregation Schemes. In International Conference on Nanotechnologies and Biomedical Engineering (pp. 361-366). Springer, Cham., 2020
• Khachatryan A., Khasaryan Sh., Tiratsuyan S., Hovhannisyan A. Antibacterial effect of silver and iron oxide Fe3O4 nanoparticles in combination with antibiotics on E. Coli. BioNanoScience, Springer New York, 5, 11-15, 2019
• Arutyunyan, A. A., Hovhannisyan, A. A., Kazaryan, S. H. A., & Tiratsuyan, S. G. Effect of silver nanoparticles on peroxidase activity of Linum ausriacum L. and Hypericum perforatum L. callus culture. Toxicon, 159, S21. DOI: 10.1016/j.toxicon.2018.11.387, 2019
• Ohanyan, S., Grabski, H., Rshtuni, L., Tiratsuyan, S. and Hovhannisyan, A., 2019, September. Improvement of the Antibacterial Activity of Benzylpenicillin in Combination with Green Silver Nanoparticles Against Staphylococcus aureus. In International Conference on Nanotechnologies and Biomedical Engineering (pp. 349-353, 2019
• Grabski H, Hunanyan L, Tiratsuyan S and Vardapetyan H. New binding site of the quorum sensing molecule N-3-Oxododecanoyl homoserine lactone with the transcriptional regulator LasR of Pseudomonas aeruginosa: insights from molecular docking and dynamics simulations [version 1; not peer reviewed]. F1000Research 2019, 6 (ISCB Comm J):1281 (poster) (doi: 10.7490/f1000research.1114539.1)
• Ginosyan S., Grabski H., Tiratsuyan S. Molecular modeling of the interaction of artemisinin with human serum albumin. Vestnik RAU, No 2, 71-80, ISBN 1829-0450
• Hambardzumyan Y., Ginosyan S., Tiratsuyan S. Comparative analysis of the inhibition potential of dihydroartemisinin dimer and ibuprofen on the aggregation of β-amyloid peptide. «Physico-Chemical Biology», Materials of VII International Scientific Internet-Conference, Stavropol, Russia, 21-24, ISBN 978-5-89822-617-6, 2019
• Ohanyan A., Shishkoyan N., Kazaryan Sh., Hovhannisyan A., Tiratsuyan S., Elbekyan K., Koshel V., Khodzhayan A. Antioxidant and Hemolytic Properties of Different Extracts from Prunella vulgaris L. Leaves. / Medical News of North Caucasus, 13(3), 507-510. , 2018
• Grabski, H. and Tiratsuyan, S. Mechanistic insights of the attenuation of quorum-sensing-dependent virulence factors of Pseudomonas aeruginosa: Molecular modeling of the interaction of taxifolin with transcriptional regulator LasR. bioRxiv, p.500157 , 2018
• Ginosyan S., Grabski H., Tiratsuyan S. The character of the artemisinin interaction with human serum albumin. «Physico-Chemical Biology», Materials of VI International Scientific Internet-Conference, Stavropol, Russia, 121-125. ISBN 978-5-89822-598-8. 2018
• Chilingaryan G., Hovhannisyan A., Ginosyan S., Tiratsuyan S. G-Quadruplex DNA Motifs Potential as Novel Antimalarial Drug Targets. «Physico-Chemical Biology», Materials of VI International Scientific Internet-Conference, Stavropol, Russia, 9-12. ISBN 978-5-89822-598-8. 2018
• Ginosyan S., Gulikyan L., Bagdasaryan A., Grabski H., Tiratsuyan S., Ayvazyan N. Characteristics of the interaction of artemisinin with glucocorticoid receptor and DNA. “Biotechnology: Forward to the future”, Materials of IV International Scientific Internet-Conference, Stavropol, Russia, 13-16. 2018
• Chiligaryan, G. V. Comparative Analysis of Quercetin and Taxifolin Interaction with Human Telomeric G-quadruplex DNA Hybrid form based on Molecular Dynamic Simulations. Հայաստանի կենսաբանական հանդես Biological Journal of Armenia Биологический журнал Армении, 70(4), 57-61. 2018
• Оганесян, А. А., Вардапетян, Г. Р., Арутюнян, А. А., Тирацуян, С. Г., Казарян, Ш. А., & Петросян, М. С. Исследование действия миллиметровых волн на антиоксидантную систему суспензионных культур Linum austriacum L. In VIII Международный конгресс" Слабые и сверхслабые поля и излучения в биологии и медицине" Научные труды Конгресса (pp. 67-68). 2018
• Tiratsuyan S.G., Grabski H.V., Gasparyan G.G. Antimicrobial activity of ethanolic extracts of selected species used in livestock health management and their major phytocompounds ФИЗИКО-ХИМИЧЕСКАЯ--БИОЛОГИЯ»материалы v международной научной интернет – конференции, 2017 г.; №3; стр.141-146, 2017
• Grabski H, Hunanyan L. Vardapetyann H., Tiratsuyan S. Reconstruction of tertiary structure of transcriptional regulator LasR of P. Aeruginosa.”Biotechnology:Forward to the future”. , 2017
• Ginosian S. Grabski H, Hunanyan L. Vardapetyann H. Tiratsuyan S. Study of the interaction of artemisinin with glucocorticoid receptor by methods of molecular modeling. “Biotechnology: Forward to the future”. 2017
• Hunanyan L., Grabski H. Chilingaryan G, Vardapetyan H. Detection of possible binding sites of quercetin on G-quadruplex DNA. Annual Yearly Conference Russian-Armenian (Slavonic) University. Grabski H., 2016
• Grabski H, Tiratsuyan S., Hunanyan L. Interaction of quercetin and morin with transcriptional regulator LasR of P. aeruginosa. «PHYSICO-CHEMICAL BIOLOGY». Materials of International Scientific Internet-Conference, Stavropol, p. 127-130, 2016,
• Grabski H, Tiratsuyan S., Hunanyan L. In-silico study of the interaction of quercetin and morin with n-3-oxo-dodecanoyl homoserine lactone by molecular modeling methods. Book of abstracts, FEBS Advanced Lecture Course, Current Advances in Pathogen Research, March 21-26, 2016, Yerevan, Armenia.
• Grabski H, Tiratsuyan S., Hunanyan L. In silico study of the interaction of morin with LasR ligand-binding domain by molecular modeling methods. Materials: International student, postgraduate and young scientist conference «Lomonosov-2016», Moscow, MSU april 11-15 2016.
• Chaltikyan G, SaghatelyanT, Buniatyan V, Begoyan V, Vardapetyan H, Tiratsuyan S, Buliev I, Bliznakov Z. New Joint Master’s Program in Biomedical Engineering (with Topics on Health ICT) in Armenia Developed through TEMPUS Project BME-ENA 2016 Global Telemedicine and Health Updates: Knowledge Resources Vol. 9, p. 161-167, 2016. ISfTeH. International Society for Telemedicine & eHealth. Printed in G. D. of Luxembourg.
• Tiratsuyan S. Hovhannisyan A. Karapetyan A. Gomktsyan T., Yengoyan A. Synthesis and biological activities of novel pyridazine derivatives. Russian journal of plant physiology, vol. 63, no. 5, pp. 656–662, 2016.
• Chaltikyan, G. Buniatyan, V. Vardapetyan, Tiratsuyan S H. Avoyan, A. Begoyan V. Saghatelyan, T. Mkrtchian, H. Aghgashyan, R. Shamakhyan, S. Buliev. Current State of Biomedical Engineering Education in Armenia and Perspectives of Development with TEMPUS IV BME-ENA Project. In 6th European Conference of the International Federation for Medical and Biological Engineering (pp. 1008-1011). Springer, Cham.
• Vardapetyan H. R, Tiratsuyan S.G., Hovhannisyan A. A. Hepatoprotective activity of leaf extract of Laurus nobilis against CCl4 induced hepatoxicity in rats. 3rd International Conference on Nano¬technologies and Bio-me¬dical Engineering, September 23-26, 2015, Chisinau, Republic of Moldova, p.419-423 • Gasparyan G., Tiratsuyan S Kazaryan Sh., Vardapetyan H. Effect of Laurus nobilis extract on the functioning of liver against CCl4 induced toxicity Journal of Experimental Biology and Agricultural Sciences, vol 3, issue 2, pp. 174-183, 2015.
• Hovhannisyan D., Gasparyan G., Tiratsuyan S Voskanyan A., Vardapetyan H. Antihemorrhagic activity of quercetin against Macrovipera lebetina obtusa venom Journal of Experimental Biology and Agricultural Sciences, vol 2, issue 2, pp. 165-170, 2014
• Vardapetyan H., Hovhannisyan D., Chailyan G. Tiratsuyan S Quercetin content and antioxidant activity of Armenian Crataegus laevigata, Plantago major and Artemisia absinthium plants extracts Journal of Experimental Biology and Agricultural Sciences, vol 2, issue 2, pp. 220-225.
• Vardapetyan H. R., Hunanyan L.S., Grabski H. V. Characteristics of the interaction of podophyllotoxin derivatives with DNA in silico. PhysioMedi Volume 2 Scientific Brochures and Booklets of the 5th International Scientific Conference "High technology, Fundamental and Practical Research in Physiology and Medicine" November 14-15 2013, Saint Petersburg. Russia. Publishing house: POLYTECHNIC INSTITUTE 2013 BBC 5:28 page 112-113.
• Vardapetyan H., Hovhannisyan Tiratsuyan S.G., A Rukhkyan M., Hovhannisyan D. Phytochemical composition and biological activityof Laurus nobilis L. leaves collected from two regions of South Caucasus JEBASciences, vol 1, issue 2, pp. 45-51.
• Martirosyan A., Vardapetyan H., Tiratsuyan S., Hovhannisyan A. Biphasic dose response of antioxidants in hypericin-induced photohemolysis 8(3) Photodiagnosis and Photodynamic Therapy 2011 p. 282-287, DOI: 0.1016/ j.pdpdt.2011.03.339
• Vardapetyan H.R., Martirosyan A.S., Tiratsuyan S.G., Hovhannisyan A.A. Investigation of the interaction of hypericin with albumin. Proc. of Int. Conf. “Biotechnology and Health-4”, Oct. 28-30, 2010, p.77-82.
• Vardapetyan H.R., Martirosyan A.S., Tiratsuyan S.G., Hovhannisyan A.A. Interaction between hypericin and hemoglobin. J. Photochem. Photobiol. B: Biol. 101 p.53-58, 2010. (IF 2.553)
• Martirosyan A.S., Vardapetyan H.R., Tiratsuyan S.G., Hovhannisyan A.A. “Possibility of improvement of hemoglobin properties as biosensors’ detection element”, Proc. SPIE, Vol. 7715, Biophotonics: Photonic Solutions for Better Health Care II, Proceedings of SPIE Vol. 7715 (SPIE, Bellingham, WA, 2010) 77153N, p.77153N-1 – 77153N-8. doi:10.1117/12.852765
• Molecular simulations and Markov state modeling reveal inactive form of quorum sensing regulator SdiA of Escherichia coli IEEE/ACM Transactions on Computational Biology and Bioinformatics. Institute of Electrical and Electronics Engineers (IEEE);2021,1-6, Available from:http://dx.doi.org/10.1109/tcbb.2021.3074567(IF: 3.015, Q2).
• Взаимодействие артемизининов с регулятором кворум-сенсинга SdiA E. coli. Биотехнология: взгляд в будущее, Материалы VII международной научно-практической конференции. Часть 1, 18-21, 2021. Биотехнология: взгляд в будущее,
• Grabski, H., Ginosyan, S. and Tiratsuyan, S., 2021. Molecular simulations and Markov state modeling reveal inactive form of quorum sensing regulator SdiA of Escherichia coli. IEEE/ACM Transactions on Computational Biology and Bioinformatics.
• Амбарцумян Е.Р., Гиносян С.В., Тирацуян С.Г. Схемы ингибирования активности BACE-1 и агрегации амилоидогенных пептидов фитопрепаратами. Биотехнология: взгляд в будущее, Материалы VII международной научно-практической конференции. Часть 1, 8-10, 2021.
• Гиносян С.В., Грабский О.В., Тирацуян С.Г. Взаимодействие артемизининов с регулятором кворум-сенсинга SdiA E. coli. Биотехнология: взгляд в будущее, Материалы VII международной научно-практической конференции. Часть 1, 18-21, 2021.
• Амбарцумян Е.Р., Гиносян С.В., Тирацуян С.Г. Анализ потенциала соединений, модулирующих мишени в разработке лекарств против болезни Альцгеймера. Материалы Международного молодежного научного форума «ЛОМОНОСОВ-2021» / Отв. ред. И.А. Алешковский, А.В. Андриянов, Е.А. Антипов, Е.И. Зимакова. ISBN 978-5-317-06593-5.
• Амбарцумян Е.Р., Гиносян С.В., Тирацуян С.Г Схемы ингибирования активности BACE-1 и агрегации амилоидогенных пептидов фитопрепаратами. Биотехнология: взгляд в будущее, Материалы VII международной научно-практической конференции. Часть 1, 8-10, 2021. ISBN 978−5−89822−581−0.
• S. Ginosyan, H. Grabski, S. Tiratsuyan. Interaction of artemisinins with quorum sensing regulator SdiA of enteropathogenic E. coli. 45th FEBS 2020 Congress, Ljubljana, Slovenia, 3-8 July 2021. Poster presentation.
• Hambardzumyan Y., Ginosyan S., Tiratsuyan S. Evaluation of the therapeutic potential of dihydroartemisinin and its dimer as β-amyloid aggregation and β-¬secretase inhibitors. The 20th FEBS Young Scientists’ Forum (YSF), June 15 - 18, 2021, Lovran, Croatia. Abstract Book, p. 97.
• Abelyan N., Grabski H., Tiratsuyan S. In silico screening of flavones and its derivatives as potential inhibitors of quorum-sensing regulator LasR of Pseudomonas aeruginosa. The 20th FEBS Young Scientists’ Forum (YSF), June 15 - 18, 2021, Lovran, Croatia. Abstract Book, p. 101.
• H Grabski, S Ginosyan, S Tiratsuyan, Molecular modeling of the interaction of taxifolin with quorum sensing regulator LasR of Pseudomonas aeruginosa 5th Int Conf on Nanotechnologies and Biomedical Engineering (ICNBME-2021).
• Оганян А.Ж., Оганесян А.А., Тирацуян С.Г , Захарян А.К.. ОЦЕНКА НЕЙТРАЛИЗУЮЩЕЙ ОКИСЛИТЕЛЬНЫЙ СТРЕСС АКТИВНОСТИ ЭКСТРАКТОВ ЛИСТЬЕВ P. VULGARIS L. И O. ARARATUM L. ПРИ БРОНХИАЛЬНОЙ АСТМЕ И ХРОНИЧЕСКОЙ ОБСТРУКТИВНОЙ БОЛЕЗНИ ЛЕГКИХ/ ПЯТНАДЦАТАЯ ГОДИЧНАЯ НАУЧНАЯ КОНФЕРЕНЦИЯ Сборник статей ЕРЕВАН 2022
• H Grabski, S Ginosyan, S Tiratsuyan Molecular Modeling of the Interaction of Taxifolin with . Quorum Sensing Regulator LasR of Pseudomonas Aeruginosa. IFMBE Proceedings. 2022, 87,429-438 https://doi.org/10.1007/978-3-030-92328-0_56, https://doi.org/10.1007/SPRINGER_CROSSMARK_POLICY
• K. E. Danielyan, H. V. Grabski, S. V. Ginosyan, S. G. Chailyan & S. G. Tiratsuyan Experimental Clarification of PRPS-1 Structural Essentials., Cell Biochemistry and Biophy sics (2022) 80:699–709 https://link.springer.com/10.1007/s12013-022-01104-1
• S.Tiratsuyan -oral presentation on 6th International Conference on Nanotechnologies and Biomedical Engineering - Proceedings of ICNBME-2023, Chishinau, MoldovaA, 23
• S.Tiratsuyan, Y Hambardzumyan, M Poghosyan, M Danielyan, A. Hovhannisyan. In vivo and in silico studies of the neuroprotective effect of artemisinin in prevention of Alzheimer's Disease in an animal model. 6th International Conference on Nanotechnologies and Biomedical Engineering - Proceedings of ICNBME-2023, Chishinau, MoldovaA Springer book series IFMBE abstract book
• S.Tiratsuyan, Y Hambardzumyan, M Poghosyan, M Danielyan, A. Hovhannisyan In vivo and in silico studies of the neuroprotective effect of artemisinin in prevention of Alzheimer's Disease in an animal model . 6th International Conference on Nanotechnologies and Biomedical Engineering - Proceedings of ICNBME-2023, Chishinau, MoldovaA Springer book series IFMBE Proceedings in [978-3-031-42781-7, ICNBME 2023, Volume 2, IFMBE Proceedings 92, schedule for paper approval (548741_1_En, Chapter 22)] International Conference on Nanotechnologies and Biomedical Engineering. – Cham : Springer Nature Switzerland, 2023. – С.
• А.Ohanyan, A.Hovhannisyan, S. Tiratsuyan Evaluation of the combined effect of Fe3O4 nanoparticles with leaf extracts of Prunella vulgaris and Ocimum araratum on hemolyzed blood peroxidase activity 47th FEBS Congress, Tours, France to be held 8-12 July, 2023 in ToursAbstract ID: 50487 Abstract Topic: Medicinalbiochemistryhttps://2023.febscongress.org /poster-guidelines;
• Е.Р.,Амбарцумян,Тирацуян С.Г. Молекулярное моделирование взаимодействия фитопрепаратов с гликогенсинтазой-3β, MARK-4 и амилоидным пептидом 18aβ9-40. Материалы IX международной научной интернет-конференции, «Биотехнология: взгляд в будущее» Ставрополь, Россия, 2023,3-5
• А.Ohanyan, A.Hovhannisyan, S. Tiratsuyan Evaluation of the combined effect of Fe3O4 nanoparticles with extracts of Prunella Vulgaris and Ocimum Araratum on hemolyzed blood peroxidase activity. 47th FEBS Congress, Tours, France to be held 8-12 July, 2023 in Tours. POSTER PRESENTATION. Scopus, Web of Science
• N. Ohanyan, N Abelyan , A Manukyan , V Hayrapetyan , S Chailyan, S. Tiratsuyan*, & K Danielyan Tannin- albumin particles as the stable carriers of the medicines. Nanomedicine (Lond.), 10.2217/nnm-2023-0275 C 2024
• Tiratsuyan, S., Hambardzumyan, Y., Poghosyan, M., Danielyan, M., Hovhannisyan, A. In vivo and in silico Studies of the Neuroprotective Effect of Artemisinin in Prevention of Alzheimer’s Disease in an Animal Model. In: ICNBME 2024. IFMBE Proceedings, vol 92. Springer, Cham. https://doi.org/10.1007/978-3-031-42782-4_22

Дисциплины

• Молекулярная биология
• Биоинженерия микроорганизмов
• Основы биотехнологии
• Клеточная инженерия
• Молекулярно-клеточные основы нейродегенеративных болезней