Описание

Научные интересы

• Иммунология
• Молекулярной иммунология
• Молекулярно-клеточная иммунология

Список основных публикаций

• 1. Manukyan G.P., Ghazaryan K.A., Ktsoyan Zh.A., Tatyan M.V., Khachatryan Z.A., Hakobyan G.S., Mkrtchyan V.A., Kelly D., Coutts A., Aminov R.I. Cytokine profile of Armenian patients with familial Mediterranean fever. Clin Biochem 2008: 41, N 10-11: 920-922.
• 2. Khachatryan Z.A., Ktsoyan Zh.A., Manukyan G.P., Ghazaryan K.A., Kelly D., Aminov R.I. Predominant role of host genetics in controlling the composition of gut microbiota. PLoS ONE 2008; 3(8):e3064:1-16.
• 3. Manukyan G.P., Ghazaryan K.A., Ktsoyan Zh.A., Khachatryan Z.A., Arakelova K.A., Kelly D., Grant G., Aminov R.I. Elevated systemic antibodies towards commensal gut microbiota in autoinflammatory condition. PLoS ONE 2008; 3(9):e3172:1-10.
• 4. Manukyan GP. Specific antibacterial antibodies in sera of patients with familial Mediterranean fever. Medical Science of Armenia 2008; 3(48):67-76
• 5. Manukyan G, Ghazaryan K, Ktsoyan Zh, Khachatryan Z, Kelly D, Tatyan M, Agababova M, Aminov R. Comparative analysis of cytokine profiles in autoinflammatory and autoimmune conditions. Cytokine 2010;50:146-151.
• 6. A. Martirosyan, G. Manukyan, K. Ghazaryan, Zh. Ktsoyan, Z. Khachatryan, M. Tatyan, R. Aminov. Multivariate analysis of cytokines as a potential meta-biomarker of disease. Biological Journal of Armenia 2010;LXII, (suppl.1):59-62.
• 7. ZA Ktsoyan, NV Beloborodova, AM Sedrakyan, GA Osipov, ZA Khachatryan, D Kelly, GP Manukyan, KA Arakelova, AI Hovhannisyan, AY Olenin, AA Arakelyan, KA Ghazaryan, RI Aminov. Profiles of microbial fatty acids in the human metabolome are disease-specific. Frontiers in Microbiology 2011;1(148):1-9. DOI: 10.3389/fmicb.2010.00148
• 8. Ktsoyan ZA, Beloborodova NV, Sedrakyan AM, Osipov GA, Khachatryan ZA, Manukyan GP, Arakelova KA, Hovhannisyan AI, Arakelyan AA, Ghazaryan KA,Zakaryan MK, Aminov RI. Management of familial Mediterranean fever by colchicine does not normalize the altered profile of microbial long chain fatty acids in the human metabolome. Front Cell Infect Microbiol 2013;3:2 . DOI: 10.3389/fcimb.2013.00002
• 9. Manukyan G, Petrek M, Kriegova E, Ghazaryan K, Fillerova R, Boyajyan A. Activated phenotype of circulating neutrophils in familial Mediterranean fever. Immunobiology 2013; 218(6):892-898. DOI: 10.1016/j.imbio.2012.10.007
• 10. Manukyan G, Petrek M, Tomankova T, Martirosyan A, Tatyan M, Navratilova Z, Paulu D, Kriegova E. Colchicine modulates expression of pro-inflammatory genes in neutrophils from patients with familial Mediterranean fever and healthy subjects. J Biol Regul Homeost Agents 2013; 27:329-336.
• 11. Ktsoyan Zh, Ghazaryan K, Manukyan G, Martirosyan A, Mnatsakanyan A, Arakelova K, Gevorgyan Z, Sedrakyan A, Asoyan A, Boyajyan A, Aminov R. Inflammatory Responses to Salmonella Infections Are Serotype-Specific. International Journal of Bacteriology 2013; ID 168179, 1-7. DOI: 10.1155/2013/168179
• 12. Manukyan G. Autoinflammation and NLRP3 inflammasome. Biology Bulletin Reviews 2015; 135(1):64-73.
• 13. Martirosyan A, Petrek M, Navratilova Z, Blbulyan A, Boyajyan A, Manukyan G. Differential regulation of proinflammatory mediators following LPS- and ATP-induced activation of monocytes from patients with Antiphospholipid Syndrome. Biomed Res Int 2015; 2015:292851. doi: 10.1155/2015/292851.
• 14. Manukyan G, Petrek M, Navratilova Z, Margaryan S, Boyajyan A. Transcriptional activity of neutrophils exposed to high doses of colchicine. J Biol Regul Homeost Agents 2015; 29(1):125-30.
• 15. Manukyan G, Aminov R, Hagobyan G, Davtyan T. Accelerated apoptosis of neutrophils in familial Mediterranean fever. Front Immunol 2015; V 6; A. 239; P. 1-7. DOI: 10.3389/fimmu.2015.00239
• 16. Manukyan G. and Aminov R. Update on pyrin functions and mechanisms of familial Mediterranean fever. Frontiers in Microbiology 2016; 7: 456. doi: 10.3389/fmicb.2016.00456. eCollection 2016.
• 17. Martirosyan A, Petrek M, Manukyan G. Extracellular ATP attenuates proinflammatory state of LPS-primed monocytes from patients with Antiphospholipid Syndrome. Biological Journal of Armenia, 26-28 Sep, Yerevan, Armenia 2016. P.89-92.
• 18. Martirosyan A, Petrek M, Kishore A, Manukyan G. The immunomodulatory effects of therapeutic plasma exchange on monocytes in Antiphospholipid syndrome. Exp Ther Med 2016; 12:1189-1195. DOI: 10.3892/etm.2016.3441
• 19. Margaryan S, Hyusyan A, Martirosyan A, Sargsian S, Manukyan G. Differential modulation of innate immune response by epinephrine and estradiol. Horm Mol Biol Clin Investig. 2017;30(3):/j/hmbci.2017.30.issue-3/hmbci-2016-0046/hmbci-2016-0046.xml. Published 2017 May 5. doi:10.1515/hmbci-2016-0046
• 20. Arleevskaya MI, Manukyan G, Inoue R and Aminov R (2017) Editorial: Microbial and Environmental Factors in Autoimmune and Inflammatory Diseases. Front. Immunol. 8:243. doi: 10.3389/fimmu.2017.00243
• 21. Malakyan M, Ayvazyan V, Manukyan G, Hovsepyan L, Arakelova E, Avetyan D, Ghazaryan H, Melkonyan A, Zakharyan R, Arakelyan A. Effects of Schiff base aromatic amino acid derivatives on antioxidant and immune system disturbances in a rat model of aflatoxin B1 induced experimental mycotoxicosis [version 1; referees: awaiting peer review]. F1000Research 2017, 6:1413
• 22. Маргарян С, Мартиртосян А, Карабон Л, Виткович А, Манукян Г. Влияние sFasL на уровни окислительного стресса в клетках врожденного иммунитета больных сахарным диабетом второго типа. Биологический журнал Армении 2017; 69:50-53
• 23. Manukyan G, Aminov R, Khachatryan Z, Yepiskoposyan L. Molecular Genetics of Familial Mediterranean Fever. eLS 2017; 1-9.
• 24. Blbulyan A, Martirosyan A, Petrek M, Navratilova Z, Manukyan G. Antiphospholipid syndrome and monocytes: new aspects. Georgian Med News. 2017;(268-269):12-17.
• 25. Margaryan S, Witkowicz A, Partyka A, Yepiskoposyan L, Manukyan G, Karabon L. The mRNA expression levels of uncoupling proteins 1 and 2 in mononuclear cells from patients with metabolic disorders: obesity and type 2 diabetes mellitus. Postepy Hig Med Dosw 2017; 71:1-6. DOI: 10.5604/01.3001.0010.5386
• 26. Manukyan G, Papajik T, Gajdos P, Mikulkova Z, Urbanova R, Gabcova G, Kudelka M, Turcsányi P, Ryznerova P, Prochazka V, Kriegova E. Neutrophils in chronic lymphocytic leukemia are permanently activated and have functional defects. Oncotarget, 2017;8:84889-84901.
• 27. Мартиросян А, Манукян Г. Теории происхождения антифосфолипидных антител: роль инфекционных патогенных агентов. Успехи современной биологии, 2018, том 138, No 2, с. 148–160.
• 28. Khondkaryan L, Margaryan S, Poghosyan D, Manukyan G. Impaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus. Int J Inflam 2018; 2157434:1-6. DOI: 10.1155/2018/2157434
• 29. Kriegova E, Manukyan G, Mikulkova Z, Gabcova G, Kudelka M, Gajdos P, Gallo J. Gender-related differences observed among immune cells in synovial fluid in knee osteoarthritis. Osteoarthritis Cartilage. 2018 Sep;26(9):1247-1256. DOI: 10.1016/j.joca.2018.04.016
• 30. Margaryan S, Witkowicz A, Arakelyan A, Partyka A, Karabon L, Manukyan G. sFasL-mediated induction of neutrophil activation in patients with type 2 diabetes mellitus. PLoS One. 2018 Jul 19;13(7):e0201087. DOI: 10.1371/journal.pone.0201087
• 31. Manukyan G, Turcsanyi P, Mikulkova Z, Gabcova G, Urbanova R, Gajdos P, Smotkova Kraiczova V, Zehnalova S, Papajik T, Kriegova E. Dynamic changes in HLA-DR expression during short-term and long-termibrutinib treatment in patients with chronic lymphocytic leukemia. Leuk Res. 2018;72:113-119.
• 32. Arleevskaya MI, Aminov R, Brooks WH, Manukyan G, Renaudineau Y. Editorial: Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms. Front Microbiol. 2019 Apr 17;10:816. DOI: 10.3389/fmicb.2019.00816
• 33. Martirosyan A, Aminov R, Manukyan G. Environmental Triggers of Autoreactive Responses: Induction of Antiphospholipid Antibody Formation. Front in Immunol. 2019; 10:1609. doi: 10.3389/fimmu.2019.01609.
• 34. Manukyan G, Martirosyan A, Slavik L, Margaryan S, Ulehlova J, Mikulkova Z, Hlusi A, Papajik T, Kriegova E. Anti-domain 1 β2 glycoprotein antibodies increase expression of tissue factor on monocytes and activate NK Cells and CD8+ cells in vitro. AutoImmun Highlights. 2020 Mar 2;11(1):5. DOI: 10.1186/s13317-020-00128-y
• 35. Margaryan S, Kriegova E, Fillerova R, Smotkova Kraiczova V, Manukyan G. Hypomethylation of IL1RN and NFKB1 Genes Is Linked to the Dysbalance in IL1β/IL-1Ra Axis in Female Patients With Type 2 Diabetes Mellitus. PLoS One. 2020 May 29;15(5):e0233737. doi: 10.1371/journal.pone.0233737.
• 36. Manukyan G, Martirosyan A, Slavik L, et al. 17β-Estradiol Promotes Proinflammatory and Procoagulatory Phenotype of Innate Immune Cells in the Presence of Antiphospholipid Antibodies. Biomedicines. 2020;8(6):E162. Published 2020 Jun 15. doi:10.3390/biomedicines8060162
• 37. Manukyan G, Papajik T, Mikulkova Z, et al. High CXCR3 on Leukemic Cells Distinguishes IgHVmut from IgHVunmut in Chronic Lymphocytic Leukemia: Evidence from CD5high and CD5low Clones. J Immunol Res. 2020;2020:7084268. doi:10.1155/2020/7084268
• 38. Mikulkova Z, Manukyan G, Turcsanyi P. et al. Deciphering the complex circulating immune cell microenvironment in chronic lymphocytic leukaemia using patient similarity networks. Sci Rep 11, 322 (2021). https://doi.org/10.1038/s41598-020-79121-4
• 39. Bradacova P, Slavik L, Ulehlova J, Skoumalova A, Ullrychova J, Prochazkova J, Hlusi A, Manukyan G, Kriegova E. Current Promising Biomarkers and Methods in the Diagnostics of Antiphospholipid Syndrome: A Review. Biomedicines. 2021 Feb 8;9(2):166. doi: 10.3390/biomedicines9020166. PMID: 33567576.

Дисциплины

• Иммунология